Healy D, O'Halloran A, Leonard B E
Int Clin Psychopharmacol. 1986 Oct;1(4):332-9. doi: 10.1097/00004850-198610000-00008.
A kinetic analysis of 5HT uptake into platelets and its inhibition by antidepressants is the most commonly used method of assessing the effects of antidepressants on 5HT uptake in humans. This study suggests that there is a naturally occurring variation in the uptake rates for 5HT into platelets, consistent with the presence of a circadian rhythm in uptake. There appears to be a derangement of this variation in depressed patients, which is reversed by effective treatment. Antidepressants may have effects both at the 5HT transport site and on the overall degree of variation. In view of this variation and its disruption in depression, it is suggested that measurement of the effects of "uptake inhibiting" drugs in depressed patients may yield different results to those obtained from controls. This difference is most apparent when uptake is measured at several time points. Furthermore, results from in vitro and ex vivo assays may yield distinctly different findings.
对5-羟色胺（5HT）摄入血小板及其受抗抑郁药抑制情况进行动力学分析，是评估抗抑郁药对人体5HT摄入影响最常用的方法。本研究表明，5HT摄入血小板的速率存在自然变异，这与摄入过程中昼夜节律的存在相一致。抑郁症患者中这种变异似乎出现紊乱，有效治疗可使其恢复正常。抗抑郁药可能在5HT转运位点以及整体变异程度方面均有作用。鉴于这种变异及其在抑郁症中的破坏情况，有人提出，测量“摄入抑制”药物对抑郁症患者的影响，可能会得到与对照组不同的结果。当在多个时间点测量摄入情况时，这种差异最为明显。此外，体外和离体试验的结果可能会产生明显不同的发现。
