Servicio de Gastroenterología, Hospital Español de México. Policlínica Ángel Urraza Saracho. México, D.F.
Ann Hepatol. 2011 Jun;10 Suppl 2:S36-9.
Hepatic encephalopathy (HE) is a heterogeneous disease that develops as a result of serious liver disease, such as in fulminant hepatitis or cirrhosis, or a portosystemic shunt. It manifests as a spectrum of abnormalities involving cognition, attention, functional ability, personality and intellect. The neuropsychiatric impairment associated with HE can range from mild alteration of cognition and consciousness to coma, depending on the stage of the illness. In 1998, the World Gastroenterology Organization formed a working party to develop guidelines and recommendations for the diagnosis, grading and treatment of HE for research and practice. In this report, we discuss the various tests available for diagnosis and grading and the recommendations of the working party, which provide a framework for further studies on clinical trial methodology.
肝性脑病（HE）是一种异质性疾病，是严重肝脏疾病（如暴发性肝炎或肝硬化，或门体分流）的结果。它表现为一系列涉及认知、注意力、功能能力、人格和智力的异常。与 HE 相关的神经精神损害范围从认知和意识轻度改变到昏迷，取决于疾病的阶段。1998 年，世界胃肠病组织成立了一个工作组，为 HE 的诊断、分级和治疗制定研究和实践的指南和建议。在本报告中，我们讨论了可用于诊断和分级的各种检测方法以及工作组的建议，为临床试验方法学的进一步研究提供了框架。
