特异性抗弓形虫IgM单样本检测在获得性弓形虫病血清学转换准确评估中的作用。
The role of single sample detection of specific anti-Toxoplasma IgM in accurate evaluation of seroconversion during acquired toxoplasmosis.
作者信息
Abdul-Fattah M M, Etewa S E, Nada S M, el-Ridi A M
机构信息
Department of Parasitology, Faculty of Medicine, Zagazig University, Egypt.
出版信息
J Egypt Soc Parasitol. 1990 Jun;20(1):175-9.
Specific IgM anti-Toxoplasma antibodies were sought in 94 serum samples by means of D.S. IgM ELISA. These antibodies were detected in all cases of acute toxoplasmic lymphadenopathy, but up to 13 months from onset of symptoms and in out of 20 patients with chronic toxoplasmosis and in one out of 20 seronegative individuals. They were neither detected in samples from 4 infants with high IgG IFAT titres associated with hydrocephalus and cerebral calcification, nor in samples from patients containing rheumatoid factors and those with lymphoma or infectious mononucleosis. Thus the detection of IgM antibodies seems non decisive mean for identifying infected infants and for determination of the exact date of acquiring the infection.
通过直接凝集试验IgM酶联免疫吸附测定法，在94份血清样本中检测特异性抗弓形虫IgM抗体。在所有急性弓形虫淋巴结病病例中均检测到这些抗体，但症状出现后长达13个月内，20例慢性弓形虫病患者中有部分患者检测到，20例血清阴性个体中有1例检测到。在4例伴有脑积水和脑钙化且IgG间接荧光抗体试验效价高的婴儿样本中未检测到，在含有类风湿因子的患者样本以及淋巴瘤或传染性单核细胞增多症患者样本中也未检测到。因此，检测IgM抗体似乎并非确定感染婴儿以及确定确切感染日期的决定性手段。
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