Maniruzzaman Mohammed, Boateng Joshua S, Snowden Martin J, Douroumis Dennis
School of Science, University of Greenwich, Central Avenue, Chatham Maritime, Chatham, Kent ME4 4TB, UK ; Department of Pharmaceutical Sciences, Medway School of Science, University of Greenwich, Chatham Maritime, Kent ME4 4TB, UK.
ISRN Pharm. 2012;2012:436763. doi: 10.5402/2012/436763. Epub 2012 Dec 27.
Over the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance and has already established its place in the broad spectrum of manufacturing operations and pharmaceutical research developments. HME has already been demonstrated as a robust, novel technique to make solid dispersions in order to provide time controlled, modified, extended, and targeted drug delivery resulting in improved bioavailability as well as taste masking of bitter active pharmaceutical ingredients (APIs). This paper reviews the innumerable benefits of HME, based on a holistic perspective of the equipment, processing technologies to the materials, novel formulation design and developments, and its varied applications in oral drug delivery systems.
在过去三十年中，工业适应性使热熔挤出（HME）得到了广泛认可，并已在广泛的制造操作和药物研发领域占据了一席之地。HME已被证明是一种强大的新型技术，可用于制备固体分散体，以实现时间控制、改良、延长和靶向给药，从而提高生物利用度，并掩盖苦味活性药物成分（API）的味道。本文基于对设备、加工技术、材料、新型制剂设计与开发以及其在口服给药系统中的各种应用的全面视角，综述了HME的诸多益处。
