• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

未分化的精神状态改变:对乙酰氨基酚中毒的晚期表现。

Undifferentiated altered mental status: a late presentation of toxic acetaminophen ingestion.

作者信息

Robey Thomas E, Melnick Edward R

机构信息

Department of Emergency Medicine, Yale University, 464 Congress Avenue, Steuite 260, New Haven, CT 06519-1315, USA.

出版信息

Case Rep Emerg Med. 2012;2012:162387. doi: 10.1155/2012/162387. Epub 2012 Jun 28.

DOI:10.1155/2012/162387
PMID:23326702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3542922/
Abstract

Altered mental status is a common undifferentiated presentation in the emergency department. We describe a case of acetaminophen-induced acute liver failure that was diagnosed and treated prior to obtaining definitive historical or laboratory information about the etiology. The physical exam finding of scleral icterus in this case was a key element to rapid identification and treatment of this life-threatening condition. A discussion of appropriate N-acetylcysteine treatment for acute liver failure and acetaminophen intoxication is included.

摘要

意识状态改变是急诊科常见的未分化表现。我们描述了一例对乙酰氨基酚所致急性肝衰竭的病例,该病例在获取有关病因的确切病史或实验室信息之前就得到了诊断和治疗。该病例中巩膜黄疸的体格检查发现是快速识别和治疗这种危及生命状况的关键因素。本文还讨论了急性肝衰竭和对乙酰氨基酚中毒的适当N - 乙酰半胱氨酸治疗方法。

相似文献

1
Undifferentiated altered mental status: a late presentation of toxic acetaminophen ingestion.未分化的精神状态改变:对乙酰氨基酚中毒的晚期表现。
Case Rep Emerg Med. 2012;2012:162387. doi: 10.1155/2012/162387. Epub 2012 Jun 28.
2
Acetaminophen and salicylate serum levels in patients with suicidal ingestion or altered mental status.有自杀性服药或精神状态改变患者的对乙酰氨基酚和水杨酸盐血清水平。
Am J Emerg Med. 1996 Sep;14(5):443-6. doi: 10.1016/S0735-6757(96)90146-1.
3
A patient-tailored N-acetylcysteine protocol for acute acetaminophen intoxication.一种针对急性对乙酰氨基酚中毒的个体化N-乙酰半胱氨酸治疗方案。
Clin Ther. 2005 Mar;27(3):336-41. doi: 10.1016/j.clinthera.2005.03.002.
4
Acetaminophen poisoning: an evidence-based consensus guideline for out-of-hospital management.对乙酰氨基酚中毒:院外管理的循证共识指南
Clin Toxicol (Phila). 2006;44(1):1-18. doi: 10.1080/15563650500394571.
5
A case of moderate liver enzyme elevation after acute acetaminophen overdose despite undetectable acetaminophen level and normal initial liver enzymes.尽管急性对乙酰氨基酚过量后检测不到对乙酰氨基酚水平且初始肝功能正常,但仍出现中度肝酶升高的病例。
Am J Ther. 2014 May-Jun;21(3):e82-4. doi: 10.1097/MJT.0b013e31824714a8.
6
Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management.对乙酰氨基酚诱导的肾毒性:病理生理学、临床表现及处理
J Med Toxicol. 2008 Mar;4(1):2-6. doi: 10.1007/BF03160941.
7
Acute poisoning following ingestion of medicines: initial management. How to treat life-threatening complications and to evaluate the risk of delayed effects and psychological distress.药物摄入后的急性中毒:初始处理。如何治疗危及生命的并发症以及评估迟发效应和心理困扰的风险。
Prescrire Int. 2010 Dec;19(111):284-91.
8
Encephalopathy in acute liver failure resulting from acetaminophen intoxication: new observations with potential therapy.对乙酰氨基酚中毒导致的急性肝衰竭脑病:新的观察结果及潜在治疗方法。
Crit Care Med. 2011 Nov;39(11):2550-3. doi: 10.1097/CCM.0b013e31822572fd.
9
Antidote removal during haemodialysis for massive acetaminophen overdose.血液透析治疗大剂量对乙酰氨基酚中毒时的解毒剂去除。
Clin Toxicol (Phila). 2013 Nov;51(9):855-63. doi: 10.3109/15563650.2013.844824.
10
Hypothermia and protection from acetaminophen-induced liver injury.
Ther Hypothermia Temp Manag. 2011;1(1):57-60. doi: 10.1089/ther.2010.0005.

本文引用的文献

1
Managing acute acetaminophen poisoning with oral versus intravenous N-acetylcysteine: a provider-perspective cost analysis.口服与静脉注射 N-乙酰半胱氨酸治疗急性对乙酰氨基酚中毒:提供者视角的成本分析。
J Med Econ. 2009;12(4):384-91. doi: 10.3111/13696990903435829.
2
Prospective study of patients with altered mental status: clinical features and outcome.对精神状态改变患者的前瞻性研究:临床特征与转归
Int J Emerg Med. 2008 Sep;1(3):179-82. doi: 10.1007/s12245-008-0049-8. Epub 2008 Sep 24.
3
Altered mental status: evaluation and etiology in the ED.意识状态改变:急诊科的评估与病因分析
Am J Emerg Med. 2002 Nov;20(7):613-7. doi: 10.1053/ajem.2002.35464.
4
Acetaminophen hepatotoxicity: the first 35 years.对乙酰氨基酚肝毒性:最初的35年。
J Toxicol Clin Toxicol. 2002;40(1):3-20. doi: 10.1081/clt-120002882.
5
N-acetylcysteine administration in the critically ill.危重症患者使用N-乙酰半胱氨酸治疗
Intensive Care Med. 1999 May;25(5):432-4. doi: 10.1007/s001340050876.
6
Dose-dependent pharmacokinetics of acetaminophen: evidence of glutathione depletion in humans.对乙酰氨基酚的剂量依赖性药代动力学:人体中谷胱甘肽耗竭的证据。
Clin Pharmacol Ther. 1987 Apr;41(4):413-8. doi: 10.1038/clpt.1987.50.
7
Early indicators of prognosis in fulminant hepatic failure.暴发性肝衰竭预后的早期指标
Gastroenterology. 1989 Aug;97(2):439-45. doi: 10.1016/0016-5085(89)90081-4.
8
Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial.静脉注射乙酰半胱氨酸治疗对乙酰氨基酚所致暴发性肝衰竭:一项前瞻性对照试验。
BMJ. 1991 Oct 26;303(6809):1026-9. doi: 10.1136/bmj.303.6809.1026.
9
Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure.乙酰半胱氨酸对暴发性肝衰竭血流动力学及氧输送的改善作用
N Engl J Med. 1991 Jun 27;324(26):1852-7. doi: 10.1056/NEJM199106273242604.
10
Varying effects of sulfhydryl nucleophiles on acetaminophen oxidation and sulfhydryl adduct formation.
Biochem Pharmacol. 1979 Oct 1;28(19):2941-6. doi: 10.1016/0006-2952(79)90590-2.