Ghalayani Parichehr, Razavi Seyed Mohammed, Gholami Darab
Associate Professor, Department of Oral Medicine and Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Dent Res J (Isfahan). 2009 Spring;6(1):1-5.
Oral lichen planus is a common mucocutaneous disorder with unknown etiology. While current data suggest that oral lichen planus is a cell-mediated disease, differential diagnosis of this disease and oral lichenoid lesions is very problematic, both clinically and histopathologically. This study aimed to compare immunohistochemical features of these similar diseases.
This was a descriptive-analytic study in which formalin-fixed and paraffin-embedded tissue sections of 30 oral lichen planus and 30 oral lichenoid lesions were immunohistochemically analyzed for number and distribution of IgG(+) cells. A standard biotin-streptavidin procedure after antigen retrieval was used. Data were analyzed in SPSS software using Mann-Whitney U test.
There were some significant differences in distribution of IgG (+)cells among different locations in oral lichen planus and also in oral lichenoid lesions separately; but the differences between distribution of IgG(+) cells between the two groups of oral lichen planus and oral lichenoid lesions were not significant.
There was no significant difference in number and distribution of IgG(+) cells between the two groups. So, this study can suggest that location of IgG is similar in samples of oral lichen planus and oral lichenoid lesions and consequently, this marker cannot help us differentiate them from each other. Other markers can be analyzed in further studies in order to find an appropriate distinguisher between the two lesions.
口腔扁平苔藓是一种病因不明的常见黏膜皮肤疾病。虽然目前的数据表明口腔扁平苔藓是一种细胞介导的疾病，但在临床和组织病理学上，该疾病与口腔苔藓样病变的鉴别诊断都非常困难。本研究旨在比较这些相似疾病的免疫组化特征。
这是一项描述性分析研究，对30例口腔扁平苔藓和30例口腔苔藓样病变的福尔马林固定石蜡包埋组织切片进行免疫组化分析，以检测IgG(+)细胞的数量和分布。采用抗原修复后的标准生物素-链霉亲和素程序。使用SPSS软件通过曼-惠特尼U检验对数据进行分析。
口腔扁平苔藓不同部位以及口腔苔藓样病变不同部位的IgG(+)细胞分布存在一些显著差异；但口腔扁平苔藓组和口腔苔藓样病变组之间IgG(+)细胞分布的差异不显著。
两组之间IgG(+)细胞的数量和分布没有显著差异。因此，本研究表明口腔扁平苔藓和口腔苔藓样病变样本中IgG的定位相似，因此，该标志物无法帮助我们区分它们。在进一步的研究中可以分析其他标志物，以便找到区分这两种病变的合适方法。
