Mathematical analysis of multisolute renal flow in a single nephron model of the kidney.

A single nephron model, which includes the Bowman's space, Cortical interstitium, and Pelvis as well-stirred baths, is investigated. A boundary value problem, which allows for pelvic reflux, is established for the fluid-multisolute flow in the nephron. The implicit function theorem is used to establish the existence and uniqueness of a solution of the boundary value problem for the case of small permeability coefficients and transport rates.