Guo Wei, Chen Wangbing, Yu Wendan, Huang Wenlin, Deng Wuguo
State Key Laboratory of Oncology in South China; Research Department, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China.
Chin J Cancer. 2013 Sep;32(9):488-93. doi: 10.5732/cjc.012.10280. Epub 2013 Jan 18.
RNA interference (RNAi) has become a gold standard for validating gene function in basic life science research and provides a promising therapeutic modality for cancer and other diseases. This mini-review focuses on the potential of small interfering RNAs (siRNAs) in anticancer treatment, including the establishment and screening of cancer-associated siRNA libraries and their applications in anticancer drug target discovery and cancer therapy. This article also describes the current delivery approaches of siRNAs using lipids, polymers, and, in particular, gold nanoparticles to induce significant gene silencing and tumor growth regression.
RNA干扰（RNAi）已成为基础生命科学研究中验证基因功能的金标准，并为癌症和其他疾病提供了一种有前景的治疗方式。本综述聚焦于小分子干扰RNA（siRNA）在抗癌治疗中的潜力，包括癌症相关siRNA文库的建立和筛选及其在抗癌药物靶点发现和癌症治疗中的应用。本文还介绍了目前使用脂质、聚合物，特别是金纳米颗粒递送siRNA的方法，以诱导显著的基因沉默和肿瘤生长消退。
