Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Soc Cogn Affect Neurosci. 2014 Apr;9(4):487-93. doi: 10.1093/scan/nst009. Epub 2013 Jan 17.
Cognitive behavioral therapy (CBT), an effective treatment for depression, targets self-referential processing of emotional stimuli. We examined the effects of CBT on brain functioning during self-referential processing in depressive patients using functional magnetic resonance imaging (fMRI). Depressive patients (n = 23) and healthy participants (n = 15) underwent fMRI scans during a self-referential task using emotional trait words. The depressive patients had fMRI scans before and after completing a total of 12 weekly sessions of group CBT for depression, whereas the healthy participants underwent fMRI scans 12 weeks apart with no intervention. Before undergoing CBT, the depressive patients showed hyperactivity in the medial prefrontal cortex (MPFC) during self-referential processing of negative words. Following CBT, MPFC and ventral anterior cingulate cortex (vACC) activity during self-referential processing among depressive patients was increased for positive stimuli, whereas it was decreased for negative stimuli. Improvements in depressive symptoms were negatively correlated with vACC activity during self-referential processing of negative stimuli. These results suggest that CBT-related improvements in depressive symptoms are associated with changes in MPFC and vACC activation during self-referential processing of emotional stimuli.
认知行为疗法 (CBT) 是一种有效的抑郁症治疗方法，针对情绪刺激的自我参照处理。我们使用功能磁共振成像 (fMRI) 检查了 CBT 对抑郁症患者自我参照处理期间大脑功能的影响。抑郁症患者 (n = 23) 和健康参与者 (n = 15) 在进行情感特质词的自我参照任务时接受了 fMRI 扫描。抑郁症患者在完成总共 12 周的团体 CBT 后接受了 fMRI 扫描，而健康参与者在没有干预的情况下相隔 12 周接受了 fMRI 扫描。在接受 CBT 之前，抑郁症患者在自我参照处理负面单词时表现出内侧前额叶皮层 (MPFC) 的过度活跃。在 CBT 之后，抑郁症患者在自我参照处理积极刺激时，MPFC 和腹侧前扣带皮层 (vACC) 的活动增加，而在自我参照处理负面刺激时则减少。抑郁症状的改善与自我参照处理负面刺激时 vACC 活动呈负相关。这些结果表明，CBT 相关的抑郁症状改善与自我参照处理情绪刺激时 MPFC 和 vACC 激活的变化有关。
