Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China; Department of Psychology, Southwest University, Chongqing, China.
Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China; Department of Psychology, Southwest University, Chongqing, China.
Psychiatry Res Neuroimaging. 2017 May 30;263:8-14. doi: 10.1016/j.pscychresns.2017.02.008. Epub 2017 Mar 3.
Self-concept is used to explain emotional disturbance or other behavioural and psychological problems associated with depression. Self-referential processing generally reflects self-concept in different domains. Cortical midline structures, such as the medial prefrontal cortex (MPFC), are critical for self-referential processing both in healthy controls and depressive patients. However, the role of subregions of the MPFC in self-referential processing in depression remains uncertain. In this study, we aimed to explore the neural basis of self-referential processing in depressive patients and the activation-deactivation patterns of subregions of the MPFC. Nineteen depressive patients and 21 controls completed the classic self-referential task with two different judgement conditions: self-referential processing and semantic processing. In the self-referential condition, with analysis of the two sample t-test unipolar patients showed significantly higher activation of the central MPFC and significantly lower activation of the dorsal MPFC, relative to controls. The results substantially suggested that the different activation of the MPFC may be selectively involved in self-referential processing in depressive patients, potentially indicating abnormal engagement of cognitive control and emotion regulation in this group.
自我概念被用来解释与抑郁相关的情绪障碍或其他行为和心理问题。自我参照加工通常反映了不同领域的自我概念。皮质中线结构，如内侧前额叶皮层（MPFC），对于健康对照组和抑郁患者的自我参照加工都很关键。然而，MPFC 的亚区在抑郁中的自我参照加工中的作用仍不确定。在这项研究中，我们旨在探讨抑郁患者自我参照加工的神经基础以及 MPFC 亚区的激活-去激活模式。19 名抑郁患者和 21 名对照者完成了经典的自我参照任务，有两种不同的判断条件：自我参照加工和语义加工。在自我参照条件下，通过双样本 t 检验分析，与对照组相比，单相抑郁患者的中央 MPFC 区激活显著升高，而背侧 MPFC 区激活显著降低。结果表明，MPFC 的不同激活可能选择性地参与了抑郁患者的自我参照加工，这可能表明该组认知控制和情绪调节的异常参与。
