Department of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109-1043, USA.
Soc Cogn Affect Neurosci. 2011 Oct;6(5):548-55. doi: 10.1093/scan/nsq080. Epub 2010 Sep 19.
Major depressive disorder (MDD) has been characterized by excessive default-network activation and connectivity with the subgenual cingulate. These hyper-connectivities are often interpreted as reflecting rumination, where MDDs perseverate on negative, self-referential thoughts. However, the relationship between connectivity and rumination has not been established. Furthermore, previous research has not examined how connectivity with the subgenual cingulate differs when individuals are engaged in a task or not. The purpose of the present study was to examine connectivity of the default network specifically in the subgenual cingulate both on- and off-task, and to examine the relationship between connectivity and rumination. Analyses using a seed-based connectivity approach revealed that MDDs show more neural functional connectivity between the posterior-cingulate cortex and the subgenual-cingulate cortex than healthy individuals during rest periods, but not during task engagement. Importantly, these rest-period connectivities correlated with behavioral measures of rumination and brooding, but not reflection.
重度抑郁症（MDD）的特征是过度默认网络激活和与扣带回下侧的连接。这些超连接通常被解释为反映沉思，其中 MDD 持续关注消极的、自我参照的想法。然而，连接性和沉思之间的关系尚未建立。此外，以前的研究尚未检查当个体参与任务或不参与任务时，与扣带回下侧的连接有何不同。本研究的目的是检查默认网络特别是在扣带回下侧的连接性，无论是在任务期间还是非任务期间，并检查连接性与沉思之间的关系。使用基于种子的连接方法的分析表明，在休息期间，MDD 比健康个体显示出更多的后扣带回皮层和扣带回下侧皮层之间的神经功能连接，但在任务参与期间没有。重要的是，这些休息期的连接性与沉思和困扰的行为测量相关，但与反思无关。
