鞘氨醇 1-磷酸是慢性炎症和结肠癌之间缺失的一环。
Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer.
机构信息
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
出版信息
Cancer Cell. 2013 Jan 14;23(1):5-7. doi: 10.1016/j.ccr.2012.12.005.
PMID:23328479
Abstract
In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-κB/IL-6/STAT3 pathway. This appears critical for progression from chronic inflammation to colon cancer.
摘要
在本期《癌细胞》中，Liang 及其同事证实，催化生物活性脂质鞘氨醇 1-磷酸形成的酶——鞘氨醇激酶 1，驱动涉及鞘氨醇 1-磷酸受体 1 和 NF-κB/IL-6/STAT3 通路的恶性扩增环。这对于从慢性炎症发展为结肠癌似乎是至关重要的。
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