Nayar J K, Knight J W, Vickery A C
Florida Medical Entomology Laboratory, University of Florida, Vero Beach 32962.
J Med Entomol. 1990 May;27(3):409-11. doi: 10.1093/jmedent/27.3.409.
Anopheles quadrimaculatus and Aedes aegypti (Black-eyed Liverpool strain) were fed on jirds and nude mice (jird-jird infection, jird-mouse infection, and mouse-jird infection) infected with subperiodic Brugia malayi and B. pahangi. Microfilariae of B. malayi from jird-mouse and mouse-jird infections developed normally in An. quadrimaculatus, whereas those from jird-jird infections did not develop. Microfilariae of both species from jirds and nude mice developed normally in Ae. aegypti and those of B. pahangi developed normally in An. quadrimaculatus. It is suggested that microfilariae from nude mice are modified physiologically, immunologically, or both so that they can develop in refractory An. quadrimaculatus, thus indicating that susceptibility and refractoriness of An. quadrimaculatus to B. malayi also is influenced by factors relating to the vertebrate host in addition to mosquito genetic factors.
四斑按蚊和埃及伊蚊（黑眼利物浦品系）吸食感染了亚周期型马来布鲁线虫和彭亨布鲁线虫的沙鼠和裸鼠（沙鼠-沙鼠感染、沙鼠-小鼠感染和小鼠-沙鼠感染）。来自沙鼠-小鼠和小鼠-沙鼠感染的马来布鲁线虫微丝蚴在四斑按蚊中正常发育，而来自沙鼠-沙鼠感染的微丝蚴则不发育。来自沙鼠和裸鼠的两种线虫的微丝蚴在埃及伊蚊中正常发育，彭亨布鲁线虫的微丝蚴在四斑按蚊中正常发育。有人提出，来自裸鼠的微丝蚴在生理或免疫或两者方面发生了改变，从而使其能够在难治性的四斑按蚊中发育，这表明四斑按蚊对马来布鲁线虫的易感性和难治性除了受蚊虫遗传因素影响外，还受到与脊椎动物宿主相关的因素影响。
