铜催化的直接 C-H 键功能化：一种区域选择性的方法，用于合成 5-芳基噻唑并[3,2-b]-1,2,4-三唑。
Cu-catalyzed direct C-H bond functionalization: a regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles.
机构信息
Key Laboratory of Mesoscopic Chemistry of Ministry of Education, Center for Multimolecular Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China.
出版信息
Org Biomol Chem. 2013 Feb 28;11(8):1390-8. doi: 10.1039/c2ob27326h.
An efficient, regioselective C-5 arylation of thiazolo[3,2-b]-1,2,4-triazoles catalyzed by a simple copper catalyst was developed. This arylation proceeded smoothly and tolerated a variety of functional groups (44 examples). A wide range of functionalized thiazolo[3,2-b]-1,2,4-triazole derivatives were obtained in high yields (up to 99% yield). Possible catalytic cycles of the arylation were also discussed.
一种简单的铜催化剂促进的噻唑并[3,2-b]-1,2,4-三唑的 C-5 区域选择性芳基化反应被开发出来。该芳基化反应进行得很顺利，可以容忍各种官能团（44 个例子）。一系列功能化的噻唑并[3,2-b]-1,2,4-三唑衍生物以高产率（高达 99%的产率）获得。还讨论了芳基化的可能催化循环。
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