全取代 1,2,3-三唑的区域选择性合成：CuAAC/C-H 键功能化连接。
Regioselective syntheses of fully-substituted 1,2,3-triazoles: the CuAAC/C-H bond functionalization nexus.
机构信息
Institut fuer Organische und Biomolekulare Chemie, Georg-August Universiteat, Tammannstrasse. 2, 37077 Göttingen, Germany.
出版信息
Org Biomol Chem. 2010 Oct 21;8(20):4503-13. doi: 10.1039/c0ob00212g. Epub 2010 Aug 23.
PMID:20733972
Abstract
Regioselective syntheses of 1,4,5-trisubstituted 1,2,3-triazoles were accomplished by three different strategies, relying on (i) the interception of stoichiometrically formed 5-cuprated-1,2,3-triazoles, (ii) the use of stoichiometrically functionalized alkynes or (iii) catalytic C-H bond functionalizations. This perspective article summarizes progress in this research area until June 2010.
摘要
通过三种不同策略，实现了 1,4,5-三取代 1,2,3-三唑的区域选择性合成，这三种策略依赖于：（i）化学计量形成的 5-三唑基铜的拦截，（ii）使用化学计量功能化的炔烃或（iii）催化 C-H 键功能化。本文综述了截至 2010 年 6 月这一研究领域的进展。
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