Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, H3T1J4, QC, Canada.
Chromosome Res. 2013 Mar;21(1):27-36. doi: 10.1007/s10577-012-9335-7. Epub 2013 Jan 18.
The Centromere is a unique chromosomal locus where the kinetochore is formed to mediate faithful chromosome partitioning, thus maintaining ploidy during cell division. Centromere identity is inherited via an epigenetic mechanism involving a histone H3 variant, called centromere protein A (CENP-A) which replaces H3 in centromeric chromatin. In spite of extensive efforts in field of centromere biology during the past decade, controversy persists over the structural nature of the CENP-A-containing epigenetic mark, both at nucleosomal and chromatin levels. Here, we review recent findings and hypotheses regarding the structure of CENP-A-containing complexes.
着丝粒是一个独特的染色体位点，在这里形成动粒以介导忠实的染色体分离，从而在细胞分裂过程中维持ploidy。着丝粒的身份是通过涉及组蛋白 H3 变体的表观遗传机制遗传的，称为着丝粒蛋白 A（CENP-A），它在着丝粒染色质中取代 H3。尽管在过去十年中在着丝粒生物学领域进行了广泛的努力，但关于含有 CENP-A 的表观遗传标记的结构性质，无论是在核小体还是染色质水平上，仍然存在争议。在这里，我们回顾了关于含有 CENP-A 的复合物结构的最新发现和假设。
