Advanced Platform Technology Center, VA Ann Arbor Healthcare System, Ann Arbor, MI 48105, USA.
Biomed Microdevices. 2013 Jun;15(3):397-406. doi: 10.1007/s10544-013-9736-1.
Microfabrication techniques are attractive for constructing artificial lungs due to the ability to create features similar in size to those in the natural lung. However, a simple and intuitive mathematical model capable of accurately predicting the gas exchange performance of microchannel artificial lungs does not currently exist. Such a model is critical to understanding and optimizing these devices. Here, we describe a simple, closed-form mathematical model for gas exchange in microchannel artificial lungs and qualify it through application to experimental data from several research groups. We utilize lumped parameters and several assumptions to obtain a closed-form set of equations that describe gas exchange. This work is intended to augment computational models by providing a more intuitive, albeit potentially less accurate, understanding of the operation and trade-offs inherent in microchannel artificial lung devices.
微制造技术因其能够创建与天然肺相似大小的特征而受到构建人工肺的青睐。然而，目前还没有一个简单直观的数学模型能够准确预测微通道人工肺的气体交换性能。这样的模型对于理解和优化这些设备至关重要。在这里，我们描述了一个用于微通道人工肺气体交换的简单闭式数学模型，并通过应用于来自几个研究小组的实验数据对其进行了验证。我们利用集中参数和几个假设，得到了一组描述气体交换的闭式方程组。这项工作旨在通过提供对微通道人工肺设备固有操作和权衡的更直观但可能不太准确的理解，来补充计算模型。
