Advanced Platform Technology Center (APT Center), Louis Stokes Cleveland VA Medical Center, Cleveland, OH 44106, USA.
Lab Chip. 2011 Sep 7;11(17):2901-9. doi: 10.1039/c1lc20020h. Epub 2011 Jul 14.
Artificial lungs have recently been utilized to rehabilitate patients suffering from lung diseases. However, significant advances in gas exchange, biocompatibility, and portability are required to realize their full clinical potential. Here, we have focused on the issues of gas exchange and portability and report a small-scale, microfabricated artificial lung that uses new mathematical modeling and a bio-inspired design to achieve oxygen exchange efficiencies much larger than current devices, thereby enabling air to be utilized as the ventilating gas. This advancement eliminates the need for pure oxygen required by conventional artificial lung systems and is achieved through a device with feature sizes and structure similar to that in the natural lung. This advancement represents a significant step towards creating the first truly portable and implantable artificial lung systems for the ambulatory care of patients suffering from lung diseases.
人工肺最近被用于康复患有肺部疾病的患者。然而，要充分发挥它们的临床潜力，还需要在气体交换、生物相容性和便携性方面取得重大进展。在这里，我们专注于气体交换和便携性问题，报告了一种小规模的、微制造的人工肺，该人工肺使用新的数学模型和仿生设计来实现比现有设备大得多的氧气交换效率，从而可以使用空气作为通风气体。这一进步消除了传统人工肺系统所需的纯氧需求，并且是通过具有类似于天然肺的尺寸和结构的设备来实现的。这一进步标志着朝着为患有肺部疾病的患者的门诊护理创建第一个真正便携和可植入的人工肺系统迈出了重要一步。
