School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
J Mater Sci Mater Med. 2013 Mar;24(3):803-9. doi: 10.1007/s10856-012-4844-7. Epub 2013 Jan 18.
Bioactive glass has been shown to stimulate bone regeneration and soft tissue healing. In this study, we evaluated the local protective effects of bioactive glass on experimental gastric ulcers, in comparison with omeprazole and hydrotalcite. Single and multiple gavage of 45S5 bioactive glass dose-dependently protected stress ulcers in mice and chronic ulcers in rats. Multi-daily gavage of bioactive glass for 7 days prevented chronic ulcer recurrence by 50 %. Bioactive glass ionic dissolution produced marked proliferation of ethanol-injured GES-1 human gastric mucosa epithelial cells 48 and 72 h after exposure. Bioactive glass was shown to be hardly absorbed after single or multi-daily gavage. This study, for the first time, demonstrates that bioactive glass is effective in protecting against gastric ulcers, with its high efficacy comparable to omeprazole and superior to hydrotalcite. The lack of oral absorption makes bioactive glass a potential for treatment of peptic ulcers omitting systemic toxicity or side-effects.
生物活性玻璃已被证明能刺激骨再生和软组织愈合。在这项研究中，我们评估了生物活性玻璃对实验性胃溃疡的局部保护作用，与奥美拉唑和水滑石进行了比较。单次和多次灌胃 45S5 生物活性玻璃可剂量依赖性地保护小鼠应激性溃疡和大鼠慢性溃疡。7 天多日灌胃生物活性玻璃可预防 50%的慢性溃疡复发。生物活性玻璃的离子溶解作用使乙醇损伤的 GES-1 人胃黏膜上皮细胞在暴露后 48 和 72 小时明显增殖。单次或多日灌胃后，生物活性玻璃几乎不被吸收。这项研究首次证明，生物活性玻璃在预防胃溃疡方面非常有效，其高疗效可与奥美拉唑相媲美，优于水滑石。由于缺乏口服吸收，生物活性玻璃有可能成为一种治疗消化性溃疡的药物，避免了全身毒性或副作用。
