Szyluk Karol, Bubnov Rostyslav, Jarosz Alicja, Reguła Rafał, Grabowski Piotr, Iwanicka Joanna, Iwanicki Tomasz, Gierek Marcin, Sieroń Dominik, Christe Andreas, Niemiec Paweł
Department of Physiotherapy, Faculty of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyków 18 Str., 40-752 Katowice, Poland.
District Hospital of Orthopaedics and Trauma Surgery, Bytomska 62 Str., 41-940 Piekary Śląskie, Poland.
J Clin Med. 2023 Dec 22;13(1):77. doi: 10.3390/jcm13010077.
Platelet-rich plasma (PRP) therapy holds substantial promise for the treatment of tennis elbow, a complex and challenging musculoskeletal condition. The aim of the study was to assess whether there are correlations between the levels of individual morphotic elements determined in whole blood and the outcomes of tennis elbow treatment with PRP injection, as measured using patient-reported outcome measures (PROMs) such as the Visual Analog Scale (VAS), Quick Disabilities of the Arm, Shoulder, and Hand (QDASH), and Patient-Rated Tennis Elbow Evaluation (PRTEE). A prospective analysis was conducted on 107 patients (132 elbows) undergoing lateral epicondylitis treatment with (PRP) injections. Patients completed VAS, PRTEE, and QDASH questionnaires on the day of PRP administration and at established checkpoints (2, 4, 8, 12, 24, 52, and 104 weeks). Minimal clinically important difference (MCID) was employed to assess the treatment effects. Then, correlations were measured within each PROM, and the impact of the concentration of individual blood parameters on the MCID outcomes was assessed. Analyzing the relationships between the MCID+ and MCID- groups, significant correlations for the VAS and QDASH scales were observed. The level of individual morphotic elements in the blood may have influenced the treatment outcome, as measured using specific patient-reported outcome measures (PROMs). Regarding the VAS scale, factors favoring a positive treatment outcome included higher values of eosinophils (EOS) and basophils (BASO). For the QDASH scale, these factors were a lower value of mean corpuscular volume (MCV) and a higher mean corpuscular hemoglobin (MCH). The levels of certain blood parameters, such as EOS and BASO, in the current study influenced the classification of patients into MCID+ or MCID- groups, based on the VAS and QDASH scales.
富血小板血浆（PRP）疗法在治疗网球肘方面具有巨大潜力，网球肘是一种复杂且具有挑战性的肌肉骨骼疾病。本研究的目的是评估全血中单个形态学元素的水平与PRP注射治疗网球肘的效果之间是否存在相关性，治疗效果通过患者报告结局量表（PROMs）来衡量，如视觉模拟量表（VAS）、手臂、肩部和手部快速残疾评估量表（QDASH）以及患者自评网球肘评估量表（PRTEE）。对107例（132个肘部）接受外侧上髁炎PRP注射治疗的患者进行了前瞻性分析。患者在PRP注射当天以及既定的检查点（2、4、8、12、24、52和104周）完成VAS、PRTEE和QDASH问卷。采用最小临床重要差异（MCID）来评估治疗效果。然后，在每个PROM内测量相关性，并评估个体血液参数浓度对MCID结果的影响。通过分析MCID+组和MCID-组之间的关系，观察到VAS和QDASH量表存在显著相关性。血液中单个形态学元素的水平可能影响了治疗结果，这是通过特定的患者报告结局量表（PROMs）来衡量的。对于VAS量表，有利于积极治疗结果的因素包括较高的嗜酸性粒细胞（EOS）和嗜碱性粒细胞（BASO）值。对于QDASH量表，这些因素是较低的平均红细胞体积（MCV）值和较高的平均红细胞血红蛋白含量（MCH）。在本研究中，某些血液参数的水平，如EOS和BASO，根据VAS和QDASH量表影响了患者分为MCID+或MCID-组的分类。
