Kuo Wen-Kai, Lee Shih-Ying, Ma Shih-Ming, Ling Tzer An, Wu Chin-Chu
Department of Cardiology, West Garden Hospital, Taiwan.
Acta Neurol Taiwan. 2012 Dec;21(4):158-64.
A correlation between carotid intima-media thickness (CIMT) and blood cells has not been well documented. Studies of a possible relationship between blood cell components and left (Lt) and right (Rt) side CIMT in asymptomatic men and women in Taiwan have not been conducted previously. The study aims to correlate factors of complete blood cells (CBC) to CIMT for men and women.
Data collection from 2767 asymptomatic healthy checkup individuals, age 35-75, 1517 men and 1250 women, were separated into four groups: CIMTML (men's Lt), CIMTMR (men's Rt), CIMTWL (women's Lt), and CIMTWR (women's Rt) for analysis of CBC factors vs. CIMT. A cut-off point for each factor was examined for the existence of significant differences in CIMT for individuals among the four test groups who had abnormal CBC data.
The regression equations of eight CBC factors vs. CIMT of four groups calculated as R2adj range were from 70.5% to 79.4%. Further comparison of CIMT in different groups by cut points of CBC factors showed significant differences in red blood cells (RBC) and platelets (PLT), but not in white blood cells (WBC).
Higher RBC, and lower mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were associated with lower CIMT in asymptomatic men in Taiwan. Further studies to confirm these differences are warranted.
颈动脉内膜中层厚度（CIMT）与血细胞之间的相关性尚未得到充分记录。此前尚未对台湾无症状男性和女性血细胞成分与左侧（Lt）和右侧（Rt）CIMT之间的可能关系进行研究。本研究旨在探讨全血细胞（CBC）各因素与男性和女性CIMT之间的相关性。
收集2767名35 - 75岁无症状健康体检者的数据，其中男性1517名，女性1250名，分为四组：男性左侧CIMT（CIMTML）、男性右侧CIMT（CIMTMR）、女性左侧CIMT（CIMTWL）和女性右侧CIMT（CIMTWR），用于分析CBC各因素与CIMT的关系。对每个因素的截断点进行检查，以确定CBC数据异常的四个测试组中个体的CIMT是否存在显著差异。
计算得出的四组中八个CBC因素与CIMT的回归方程的调整R²范围为70.5%至79.4%。通过CBC因素的截断点对不同组的CIMT进行进一步比较，结果显示红细胞（RBC）和血小板（PLT）存在显著差异，而白细胞（WBC）无显著差异。
在台湾无症状男性中，较高的RBC、较低的平均红细胞体积（MCV）和平均红细胞血红蛋白含量（MCH）与较低的CIMT相关。有必要进行进一步研究以证实这些差异。
