Zanetti A R, Ferroni P, Bastia A
Boll Ist Sieroter Milan. 1979 Jan 31;57(6):816-20.
The availability of serum samples collected in 1958 and in 1977 from healthy individuals of Milan, has provided an opportunity to compare the prevalence of anti-HAV and anti-HBs in the same area at a distance of about 20 years. The results obtained show a general drop of anti-HAV rate from 1958 to 1977. Difference in antibody prevalence was found to be significantly remarkable (35.7% versus 3.6%, P < 0.05 and 78.6% versus 26.9%, P < 0.01) in the youngest age groups examined (1-5 and 6-15 years old). Moreover the plateau of antibody acquisition was reached over 30 years of age in people selected in 1958 and over 50 years in 1977. No substantial difference was found in anti-HBs prevalence in sera collected in 1958 and in 1977 (29.2% versus 29.3%). The finding of a decline in hepatitis A infection may reflect the improvements in public health and hygienic conditions which occurred in our city in the last decades, whereas with regard to hepatitis B, the maintenance of the same incidence of infection may be due to different contributory factors.
1958年和1977年从米兰健康个体采集的血清样本，为比较同一地区相隔约20年的抗甲型肝炎病毒（anti-HAV）和抗乙型肝炎病毒（anti-HBs）流行率提供了机会。所得结果显示，从1958年到1977年抗甲型肝炎病毒率普遍下降。在所检查的最年轻年龄组（1 - 5岁和6 - 15岁）中，抗体流行率差异非常显著（分别为35.7%对3.6%，P < 0.05；78.6%对26.9%，P < 0.01）。此外，1958年所选人群中30岁以上达到抗体获得平稳期，1977年则为50岁以上。1958年和1977年采集的血清中抗乙型肝炎病毒流行率未发现实质性差异（分别为29.2%对29.3%）。甲型肝炎感染率下降这一发现可能反映了过去几十年我们城市公共卫生和卫生条件的改善，而对于乙型肝炎，感染率维持不变可能是由于不同的促成因素。
