米兰健康个体中甲型肝炎病毒抗体的流行情况。

Prevalence of antibody to hepatitis A virus in healthy individuals of Milan.

作者信息

Zanetti A R, Ferroni P

出版信息

Boll Ist Sieroter Milan. 1978 Sep 30;57(4):523-7.

Abstract

We have studied by radioimmunoassay the prevalence of antibody to hepatitis A virus in 436 randomly selected individuals of Milan according to age and sex. Taken together, 70% of subjects provided serological evidence of exposure to HAV. Both sexes resulted similarly immunized (69.7% females and 70.7% males). The anti-HAV prevalence was found to be directly related to age, being on the increase from childhood to adulthood and reaching its peak (9l.5%) in people over fifty. An analysis of the distribution of anti-HAV according to presence or absence of anti-HBs in induviduals under 30 years, revealed that anti-HAV was detectable more frequently in individuals anti-HBs positive than in those without such evidence in sera (71.4% versus 39.7%; P less than 0.01). Finally, 96 sera from children and adolescents of low socioeconomic standard of living were also investigated. In these subjects anti-HAV prevalence was found to be higher than in their counterparts randomly slected from general population.

摘要

我们通过放射免疫分析法，根据年龄和性别对米兰随机抽取的436名个体进行了甲型肝炎病毒抗体流行率的研究。总体而言，70%的受试者提供了接触甲型肝炎病毒的血清学证据。男女免疫情况相似（女性为69.7%，男性为70.7%）。发现抗甲型肝炎病毒流行率与年龄直接相关，从儿童期到成年期呈上升趋势，在50岁以上人群中达到峰值（91.5%）。对30岁以下个体根据有无抗乙型肝炎表面抗原（抗-HBs）情况进行抗甲型肝炎病毒分布分析发现，抗-HBs阳性个体中抗甲型肝炎病毒的检出频率高于血清中无此证据的个体（71.4%对39.7%；P<0.01）。最后，还对96份来自社会经济生活水平较低的儿童和青少年的血清进行了研究。在这些受试者中，发现抗甲型肝炎病毒流行率高于从普通人群中随机抽取的同龄对照者。