Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, The University of Sydney, Darlington, New South Wales, Australia.
Invest Ophthalmol Vis Sci. 2013 Feb 27;54(2):1501-8. doi: 10.1167/iovs.12-11036.
We aimed to establish whether the change in retinal microvascular structure observed cross-sectionally with axial elongation and larger corneal curvature is comparable from early childhood to adolescence.
In all, 1077 Sydney Paediatric Eye Study participants (36 to <72 months of age) and 1740, 2353, and 1216 from the Sydney Childhood Eye Study (6, 12, and 17 years of age), respectively, were examined. Quantifiable retinal vascular caliber measurements were obtained using validated computer-based methods. Ocular biometry measurements were performed according to standardized protocols.
After multivariable adjustment, in children 36 to <72 months of age, each 1.0-mm increase in axial length was associated with a 3.67- and 6.53-μm narrowing of mean retinal arteriolar caliber (P = 0.005) and venular caliber (P < 0.0001), respectively. Each 1.0-mm increase in axial length in children 6, 12, and 17 years of age was associated with a 5.30-, 3.96-, and 4.03-μm decrease in mean retinal arteriolar caliber, respectively. Each 1.0-mm increase in axial length in children 6, 12, and 17 years of age was associated with a 7.12-, 6.72-, and 6.85-μm decrease in retinal venular caliber, respectively. Corneal curvature was inversely associated with retinal vascular caliber among all age groups (P < 0.001). Among those without significant refractive error (>0.00 and <2.00 diopters), significant inverse associations were observed between axial length and corneal curvature with retinal vessel caliber among all age groups.
We demonstrate a similar magnitude of retinal vessel narrowing with axial length elongation and increasing corneal curvature from childhood through to adolescence. These data confirm the robustness of the associations between ocular biometric traits and retinal microvascular structural changes during childhood development.
我们旨在确定从儿童早期到青春期，随着眼轴延长和更大的角膜曲率的改变而观察到的视网膜微血管结构的变化是否具有可比性。
总共纳入了 1077 名悉尼儿科眼部研究参与者（36 至<72 个月龄）和 1740、2353 和 1216 名悉尼儿童眼部研究参与者（6、12 和 17 岁）。使用经过验证的基于计算机的方法获得可量化的视网膜血管口径测量值。根据标准化方案进行眼生物测量测量。
在 36 至<72 个月龄的儿童中，经过多变量调整后，眼轴每增加 1.0mm，平均视网膜小动脉口径（P=0.005）和小静脉口径（P<0.0001）分别变窄 3.67-μm 和 6.53-μm。6、12 和 17 岁儿童的眼轴每增加 1.0mm，平均视网膜小动脉口径分别减少 5.30-μm、3.96-μm 和 4.03-μm。6、12 和 17 岁儿童的眼轴每增加 1.0mm，视网膜小静脉口径分别减少 7.12-μm、6.72-μm 和 6.85-μm。在所有年龄组中，角膜曲率与视网膜血管口径呈负相关（P<0.001）。在没有明显屈光不正（>0.00 和<2.00 屈光度）的人群中，在所有年龄组中，眼轴与角膜曲率与视网膜血管口径之间均存在显著的负相关关系。
我们证明了从儿童期到青春期，眼轴延长和角膜曲率增加与视网膜血管变窄的程度相似。这些数据证实了在儿童发育过程中，眼球生物测量特征与视网膜微血管结构变化之间的关联具有稳健性。
