Tai Evelyn Li Min, Li Ling-Jun, Wan-Hazabbah Wan Hitam, Wong Tien-Yin, Shatriah Ismail
Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
PLoS One. 2017 Jan 20;12(1):e0170014. doi: 10.1371/journal.pone.0170014. eCollection 2017.
Retinal vessel analysis is affected by both systemic and ocular factors. Malays are the major ethnicity in South East Asia. Data on the retinal microvasculature in Malays is limited, especially among children. We aim to evaluate the influence of ocular biometry on retinal vessel parameters in young Malay girls.
This was a cross-sectional, hospital-based study involving 86 Malay girls aged 6 to 12 years old in Hospital Universiti Sains Malaysia from 2015-2016. Ocular examination, refraction, biometry, retinal photography, and anthropometric measurements were performed. The central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) and overall fractal dimension (Df) were measured using validated computer-based methods (Singapore I vessel analyzer, SIVA version 3.0, Singapore). The associations of ocular biometry and CRAE, CRVE and Df were analyzed using multivariable analysis.
The mean CRAE, CRVE and Df in Malay girls were 171.40 (14.40) um, 248.02 (16.95) um and 1.42 (0.05) respectively. Each 1 mm increase in axial length was associated with a reduction of 4.25 um in the CRAE (p = 0.03) and a reduction of 0.02 in the Df (p = 0.02), after adjustment for age, blood pressure and body mass index. No association was observed between axial length and CRVE. Anterior chamber depth and corneal curvature had no association with CRAE, CRVE or Df.
Axial length affects retinal vessel measurements. Narrower retinal arterioles and reduced retinal fractal dimension were observed in Malay girls with longer axial lengths.
视网膜血管分析受到全身因素和眼部因素的影响。马来人是东南亚的主要族群。关于马来人视网膜微血管的数据有限，尤其是在儿童中。我们旨在评估眼部生物测量对年轻马来女孩视网膜血管参数的影响。
这是一项基于医院的横断面研究，于2015年至2016年在马来西亚理科大学医院纳入了86名6至12岁的马来女孩。进行了眼部检查、验光、生物测量、视网膜摄影和人体测量。使用经过验证的基于计算机的方法（新加坡I血管分析仪，SIVA版本3.0，新加坡）测量中心视网膜动脉等效直径（CRAE）、中心视网膜静脉等效直径（CRVE）和整体分形维数（Df）。使用多变量分析分析眼部生物测量与CRAE、CRVE和Df之间的关联。
马来女孩的平均CRAE、CRVE和Df分别为171.40（14.40）μm、248.02（16.95）μm和1.42（0.05）。在调整年龄、血压和体重指数后，眼轴长度每增加1mm，CRAE减少4.25μm（p = 0.03），Df减少0.02（p = 0.02）。未观察到眼轴长度与CRVE之间的关联。前房深度和角膜曲率与CRAE、CRVE或Df无关联。
眼轴长度影响视网膜血管测量。在眼轴较长的马来女孩中观察到视网膜动脉较窄且视网膜分形维数降低。
