Komarowska Marta Diana, Hermanowicz Adam, Matuszczak Ewa, Oksiuta Marzanna, Dzienis-Koronkiewicz Ewa, Zelazowska-Rutkowska Beata, Debek Wojciech
Medical University of Bialystok, Pediatric Surgery, Waszyngtona 17 Bialystok 15-274, Poland.
J Pediatr Endocrinol Metab. 2012;25(11-12):1073-6. doi: 10.1515/jpem-2012-0210.
The aim of this study was to determine the serum anti-Müllerian hormone (AMH levels) in a group of boys with cryptorchidism before and 1 year after surgery. Additionally, the effect of orchiopexy, based on the testicular position and morphology, was evaluated. Fifty boys who were 1-4 years old (median, 2.4 years) with unilateral cryptorchidism were evaluated before and 1 year after they underwent orchiopexy. Prior to the procedure, all of the patients had undergone karyotyping to exclude chromosomal abnormalities. Blood samples were collected while obtaining blood for standard laboratory tests routinely performed just before and 12 months after surgery. Twelve months after the orchiopexy, in most cases surgically treated testes were in the middle or lower pole of the scrotum. The descended glands were of comparable size and density in comparison with the testes on the opposite side. In the treated children, serum AMH levels measured at 12 months after orchiopexy were similar to preoperative basal levels. The authors found that AMH levels in children with unilateral undescended testes do not change significantly 1 year after surgical procedure. We still do not have trustworthy factors to predict fertility in children affected with cryptorchidism. We observed an upward trend in AMH concentration 1 year after orchiopexy, but it was statistically insignificant. Therefore, we plan further measurements of AMH in boys after orchiopexy to assess the influence of this procedure on gonadal function.
本研究的目的是测定一组隐睾症男孩手术前后血清抗苗勒管激素（AMH水平）。此外，根据睾丸位置和形态评估睾丸固定术的效果。对50例1-4岁（中位年龄2.4岁）单侧隐睾症男孩在接受睾丸固定术前及术后1年进行评估。在手术前，所有患者均进行了核型分析以排除染色体异常。在手术前和术后12个月常规进行标准实验室检查取血时采集血样。睾丸固定术后12个月，在大多数情况下，手术治疗的睾丸位于阴囊中极或下极。与对侧睾丸相比，下降的睾丸大小和密度相当。在接受治疗的儿童中，睾丸固定术后12个月测得的血清AMH水平与术前基础水平相似。作者发现，单侧隐睾症儿童术后1年AMH水平无显著变化。我们仍然没有可靠的因素来预测受隐睾症影响儿童的生育能力。我们观察到睾丸固定术后1年AMH浓度有上升趋势，但无统计学意义。因此，我们计划对睾丸固定术后男孩进一步测定AMH，以评估该手术对性腺功能的影响。
