Catli Gonul, Abaci Ayhan, Altincik Ayca, Demir Korcan, Can Sule, Buyukgebiz Atilla, Bober Ece
Department of Pediatric Endocrinology, School of Medicine, Dokuz Eylul University, 35340 Balcova, Izmir, Turkey.
J Pediatr Endocrinol Metab. 2012;25(11-12):1123-8. doi: 10.1515/jpem-2012-0130.
Hyperprolactinemia is a rare endocrine disorder in childhood, which may result from hypophyseal adenoma. We aimed to review the etiologic reasons and clinical features in hyperprolactinemia patients retrospectively. The mean age of 11 female patients at diagnosis was 14.2 ± 1.3 years. Five patients had microadenoma, four patients had macroadenoma, and two patients were diagnosed with idiopathic hyperprolactinemia. The most frequent symptoms were menstrual disorders, headache, and galactorrhea, and one-third of the patients had obesity at diagnosis. There was no anterior pituitary hormone deficiency. All patients received bromocriptine as initial therapy; only two patients with macroadenoma and one patient with microadenoma were switched to cabergoline. Transsphenoidal surgery was performed for a patient with macroadenoma, who had cavernous sinus invasion and visual field defect. Medical treatment should be the first-line treatment option in both microadenoma and macroadenoma cases without any neurological signs. Surgery should be employed with limited indications.
高催乳素血症是一种儿童期罕见的内分泌疾病，可能由垂体腺瘤引起。我们旨在回顾性分析高催乳素血症患者的病因及临床特征。11例女性患者确诊时的平均年龄为14.2±1.3岁。5例为微腺瘤，4例为大腺瘤，2例诊断为特发性高催乳素血症。最常见的症状是月经紊乱、头痛和溢乳，三分之一的患者在确诊时有肥胖。无垂体前叶激素缺乏。所有患者均接受溴隐亭作为初始治疗；仅2例大腺瘤患者和1例微腺瘤患者改用卡麦角林。对1例有海绵窦侵犯和视野缺损的大腺瘤患者进行了经蝶窦手术。对于无任何神经体征的微腺瘤和大腺瘤病例，药物治疗应作为一线治疗选择。手术适应证应严格限制。
