马体内普罗帕酮的动力学。房室模型与非房室模型的比较分析。

Propafenone kinetics in the horse. Comparative analysis of compartmental and noncompartmental models.

作者信息

Puigdemont A, Riu J L, Guitart R, Arboix M

机构信息

Departament de Farmacologia, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, Spain.

出版信息

J Pharmacol Methods. 1990 Apr;23(2):79-85. doi: 10.1016/0160-5402(90)90035-j.

DOI:10.1016/0160-5402(90)90035-j

PMID:2332982

Abstract

The propafenone kinetics after intravenous (i.v.) administration have been studied in the horse by a comparative analysis of compartmental and noncompartmental models. The pharmacokinetic parameters showed a large distribution (Vdss = 1021 +/- 211 L) and a high clearance (CI = 7019 +/- 1746 mL/min) of the drug. The plasma concentrations were very low, under 1 microgram/mL, in most cases; after 30 min these concentrations can be considered as nonefficient for the treatment of arrhythmia. There were no significant differences between pharmacokinetic parameters found with the use of compartmental and noncompartmental models.

摘要

通过房室模型和非房室模型的比较分析，对马静脉注射普罗帕酮后的动力学进行了研究。药代动力学参数显示该药物具有较大的分布容积（稳态分布容积Vdss = 1021±211 L）和较高的清除率（CI = 7019±1746 mL/分钟）。在大多数情况下，血浆浓度非常低，低于1微克/毫升；30分钟后，这些浓度可被认为对心律失常治疗无效。使用房室模型和非房室模型所发现的药代动力学参数之间没有显著差异。