在发育过程中黏蛋白型 O-糖基化。
Mucin-type O-glycosylation during development.
机构信息
Developmental Glycobiology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892-4370, USA.
出版信息
J Biol Chem. 2013 Mar 8;288(10):6921-9. doi: 10.1074/jbc.R112.418558. Epub 2013 Jan 17.
Abstract
Mucin-type O-glycosylation is an evolutionarily conserved protein modification present on membrane-bound and secreted proteins. Aberrations in O-glycosylation are responsible for certain human diseases and are associated with disease risk factors. Recent studies have demonstrated essential roles for mucin-type O-glycosylation in protein secretion, stability, processing, and function. Here, we summarize our current understanding of the diverse roles of mucin-type O-glycosylation during eukaryotic development. Appreciating how this conserved modification operates in developmental processes will provide insight into its roles in human disease and disease susceptibilities.
摘要
黏蛋白型 O-糖基化是一种存在于膜结合蛋白和分泌蛋白上的保守蛋白修饰。O-糖基化的异常与某些人类疾病有关，并与疾病风险因素有关。最近的研究表明，黏蛋白型 O-糖基化在蛋白质分泌、稳定性、加工和功能中起着重要作用。在这里，我们总结了我们目前对黏蛋白型 O-糖基化在真核生物发育过程中多种作用的理解。了解这种保守修饰在发育过程中的作用方式将为其在人类疾病和疾病易感性中的作用提供深入的认识。
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