人类结肠癌和乳腺癌中的粘蛋白型O-聚糖：糖动力学与功能
Mucin-type O-glycans in human colon and breast cancer: glycodynamics and functions.
作者信息
Brockhausen Inka
机构信息
Department of Medicine and Biochemistry, Human Mobility Research Centre, Queen's University, Kingston General Hospital, Angada 1, Kingston, Ontario K7L 2V7, Canada.
出版信息
EMBO Rep. 2006 Jun;7(6):599-604. doi: 10.1038/sj.embor.7400705.
Abstract
The glycoproteins of tumour cells are often abnormal, both in structure and in quantity. In particular, the mucin-type O-glycans have several cancer-associated structures, including the T and Tn antigens, and certain Lewis antigens. These structural changes can alter the function of the cell, and its antigenic and adhesive properties, as well as its potential to invade and metastasize. Cancer-associated mucin antigens can be exploited in diagnosis and prognosis, and in the development of cancer vaccines. The activities and Golgi localization of glycosyltransferases are the basis for the glycodynamics of cancer cells, and determine the ranges and amounts of specific O-glycans produced. This review focuses on the glycosyltransferases of colon and breast cancer cells that determine the pathways of mucin-type O-glycosylation, and the proposed functional and pathological consequences of altered O-glycans.
摘要
肿瘤细胞的糖蛋白在结构和数量上常常异常。特别是，粘蛋白型O-聚糖具有几种与癌症相关的结构，包括T和Tn抗原以及某些Lewis抗原。这些结构变化可改变细胞的功能、抗原性和黏附特性，以及其侵袭和转移的潜能。癌症相关的粘蛋白抗原可用于诊断、预后评估以及癌症疫苗的研发。糖基转移酶的活性和高尔基体定位是癌细胞糖动力学的基础，并决定了特定O-聚糖的产生范围和数量。本综述重点关注决定粘蛋白型O-糖基化途径的结肠癌细胞和乳腺癌细胞的糖基转移酶，以及O-聚糖改变所带来的潜在功能和病理后果。
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本文引用的文献
1
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Glycoconj J. 2006 Nov;23(7-8):525-41. doi: 10.1007/s10719-006-7153-x.
2
O-glycosylated versus non-glycosylated MUC1-derived peptides as potential targets for cytotoxic immunotherapy of carcinoma.O-糖基化与非糖基化的MUC1衍生肽作为癌症细胞毒性免疫治疗的潜在靶点
Clin Exp Immunol. 2006 Jan;143(1):139-49. doi: 10.1111/j.1365-2249.2005.02965.x.
3
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J Biol Chem. 2006 Feb 10;281(6):3586-94. doi: 10.1074/jbc.M511826200. Epub 2005 Nov 30.
4
The cooperation between two CD4 T cells induces tumor protective immunity in MUC.1 transgenic mice.两个CD4 T细胞之间的合作在MUC.1转基因小鼠中诱导肿瘤保护性免疫。
J Immunol. 2005 Nov 15;175(10):6551-9. doi: 10.4049/jimmunol.175.10.6551.
5
UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 as a new immunohistochemical breast cancer marker.UDP-N-乙酰-D-半乳糖胺：多肽N-乙酰半乳糖胺基转移酶-6作为一种新的免疫组化乳腺癌标志物。
J Histochem Cytochem. 2006 Mar;54(3):317-28. doi: 10.1369/jhc.5A6783.2005. Epub 2005 Oct 31.
6
Siglecs--the major subfamily of I-type lectins.唾液酸结合免疫球蛋白样凝集素——I型凝集素的主要亚家族。
Glycobiology. 2006 Jan;16(1):1R-27R. doi: 10.1093/glycob/cwj008. Epub 2005 Jul 13.
7
Siglecs in innate immunity.Siglecs在固有免疫中的作用。 （这里根据语境意译，原文标题直译是“固有免疫中的Siglecs”，意译更符合一般学术文章标题风格）
Curr Opin Pharmacol. 2005 Aug;5(4):431-7. doi: 10.1016/j.coph.2005.03.003.
8
Stable expression of sialyl-Tn antigen in T47-D cells induces a decrease of cell adhesion and an increase of cell migration.唾液酸-Tn抗原在T47-D细胞中的稳定表达导致细胞黏附减少和细胞迁移增加。
Breast Cancer Res Treat. 2005 Mar;90(1):77-84. doi: 10.1007/s10549-004-3137-3.
9
The effect of TNF-alpha on glycosylation pathways in bovine synoviocytes.肿瘤坏死因子-α对牛滑膜细胞糖基化途径的影响。
Biochem Cell Biol. 2004 Oct;82(5):559-68. doi: 10.1139/o04-058.
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