Johari Khatoonabad M, Aghamohammadzade N, Taghilu H, Esmaeili F, Jabbari Khamnei H
Assistant Professor, Department of Oral and Maxillofacial Radiology, Dental Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.
Iran J Radiol. 2011 Mar;8(1):23-8. Epub 2011 Mar 30.
BACKGROUND/OBJECTIVE: Recent investigations have shown that panoramic radiography might be a useful tool in the early diagnosis of osteoporosis. In addition, bone turnover biochemical markers might be valuable in predicting osteoporosis and fracture risks in the elderly, especially in post-menopausal women. The aim of the present study was to evaluate the relationship among the radiomorphometric indices of the mandible, biochemical markers of the bone turnover and hip BMD in a group of post-menopausal women.
Evaluations of mandibular cortical width (MCW), mandibular cortical index (CI), panoramic index (PMI) and alveolar crest resorption ratio (M/M ratio) were carried out on panoramic radiographs of 140 post-menopausal women with an age range of 44-82 years. Hip BMD was measured by DEXA method. BMD values were divided into three groups of normal (T score>-1.0), osteopenic (T score, -2.5 to -1.0) and osteoporotic (T score<-2.5). Serum alkaline phosphatase and 25(OH) D(3) were measured.
A decrease in MCW by 1 mm increases the likelihood of osteopenia or osteoporosis up to 40%, having taken into consideration the effect of menopause duration. A 1 mm decrease in MCW increased the likelihood of moderate or severe erosion of the lower cortex of the mandible up to 28% by taking age into consideration. The results did not demonstrate a statistically significant relationship between bone turnover markers and mandibular radiomorphometric indices.
Panoramic radiography gives sufficient information to make an early diagnosis regarding osteoporosis in post-menopausal women. Panoramic radiographs may be valuable in the prevention of osteoporotic fractures in elderly women.
背景/目的：近期研究表明，全景X线摄影可能是骨质疏松症早期诊断的一种有用工具。此外，骨转换生化标志物对于预测老年人尤其是绝经后女性的骨质疏松症和骨折风险可能具有重要价值。本研究的目的是评估一组绝经后女性下颌骨的放射形态计量学指标、骨转换生化标志物与髋部骨密度之间的关系。
对140名年龄在44 - 82岁之间的绝经后女性的全景X线片进行下颌骨皮质宽度（MCW）、下颌骨皮质指数（CI）、全景指数（PMI）和牙槽嵴吸收比（M/M比）的评估。采用双能X线吸收法测量髋部骨密度。骨密度值分为正常（T值＞-1.0）、骨量减少（T值，-2.5至-1.0）和骨质疏松（T值＜-2.5）三组。检测血清碱性磷酸酶和25(OH)D(3)。
考虑到绝经持续时间的影响，MCW每减少1mm，骨量减少或骨质疏松的可能性增加高达40%。考虑到年龄因素，MCW每减少1mm，下颌骨下部皮质中度或重度侵蚀的可能性增加高达28%。结果未显示骨转换标志物与下颌骨放射形态计量学指标之间存在统计学上的显著关系。
全景X线摄影可为绝经后女性骨质疏松症的早期诊断提供足够信息。全景X线片对于预防老年女性骨质疏松性骨折可能具有重要价值。
