斑秃患者的头皮链格孢菌感染。是共存还是因果关系？
Alternaria scalp infection in a patient with alopecia areata. Coexistence or causative relationship?
作者信息
Rudnicka Lidia, Lukomska Malgorzata
机构信息
Department of Dermatology CSK MSW, Warsaw, Poland ; Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland ; Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland.
出版信息
J Dermatol Case Rep. 2012 Dec 31;6(4):120-4. doi: 10.3315/jdcr.2012.1120.
Abstract
BACKGROUND
Alopecia areata is an autoimmune disease that is affecting anagen hair follicles. The triggers of autoimmunity in patients with alopecia areata remain unknown.
MAIN OBSERVATION
A 13-year-old boy developed multiple hairless patches of focal hair loss with typical clinical and trichoscopy features of alopecia areata. Mycology examination of the scalp hair and epidermal scrapings reveled massive growth of Alternaria chlamydospora.
CONCLUSION
We hypothesize that fungal antigens (e.g. antigens involved in fungal melanin synthesis) may be possible triggers, contributing to autoimmune reactions in patients with alopecia areata. We discuss research data, which may indirectly support this hypothesis, however the concept has yet to be verified.
摘要
背景
斑秃是一种影响生长期毛囊的自身免疫性疾病。斑秃患者自身免疫的触发因素仍不清楚。
主要观察结果
一名13岁男孩出现多处局限性脱发的无毛斑，具有典型的斑秃临床和毛发镜特征。头皮毛发和表皮刮屑的真菌学检查显示链格孢大量生长。
结论
我们推测真菌抗原（如参与真菌黑色素合成的抗原）可能是导致斑秃患者自身免疫反应的触发因素。我们讨论了可能间接支持这一假设的研究数据，然而这一概念尚未得到证实。
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