Skorkina M Yu, Fedorova M Z, Muravyov A V, Sladkova E A
Belgorod State National Research University, Russia.
Bull Exp Biol Med. 2012 Nov;154(1):163-6. doi: 10.1007/s10517-012-1899-x.
Tapping mode-atomic force microscopy and force spectroscopy were used for studies of the topography of the cell surface and elastic properties of lymphocytes from healthy donors and patients with chronic lymphoblastic leukemia. It was demonstrated that the decrease in lymphocytes stiffness in patients with chronic lymphoblastic leukemia by 51.4% (p<0.05) was accompanied by spatial modification of the cell surface, in particular, increase in the number of globular protrusions and depressions by 247 and 122%, respectively (p<0.05), in comparison with normal lymphocytes.
轻敲模式原子力显微镜和力谱法被用于研究健康供体和慢性淋巴细胞白血病患者淋巴细胞的细胞表面形貌和弹性特性。结果表明，慢性淋巴细胞白血病患者淋巴细胞的硬度降低了51.4%（p<0.05），同时细胞表面发生了空间变化，特别是与正常淋巴细胞相比，球状突起和凹陷的数量分别增加了247%和122%（p<0.05）。
