Kuznetsova S A, Starikova E A, Freidlin I S, Smirnov V S
Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, Russia.
Bull Exp Biol Med. 2012 Dec;154(2):237-40. doi: 10.1007/s10517-012-1921-3.
Imiquimod (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine) is an active immunomodulator with antiviral effects. In addition to its stimulatory effect on cell-mediated immunity, in vivo studies have detected its antiviral and antiangiogenic effects. Possible direct effect of imiquimod on endothelial cells remains not studied. We have shown that imiquimod inhibited proliferation and migration of human endothelial cells (EA.hy 926 strain) in vitro and induced apoptosis (but not necrosis) of endothelial cells and production of IL-6 cytokine. These results suggest that imiquimod inhibits angiogenesis via direct modulation of endothelial cell function.
咪喹莫特（1-(2-甲基丙基)-1H-咪唑并[4,5-c]喹啉-4-胺）是一种具有抗病毒作用的活性免疫调节剂。除了对细胞介导的免疫有刺激作用外，体内研究还检测到其抗病毒和抗血管生成作用。咪喹莫特对内皮细胞可能的直接作用尚未得到研究。我们已经表明，咪喹莫特在体外抑制人内皮细胞（EA.hy 926株）的增殖和迁移，并诱导内皮细胞凋亡（而非坏死）以及IL-6细胞因子的产生。这些结果表明，咪喹莫特通过直接调节内皮细胞功能来抑制血管生成。
