Abakumov M A, Shein S A, Vishvasrao H, Nukolova N V, Sokol'ski-Papkov M, Sandalova T O, Gubskii I L, Grinenko N F, Kabanov A V, Chekhonin V P
Department of Medical Nanobiotechnologies, N. I. Pirogov Russian National Research Medical University, Moscow, Russia.
Bull Exp Biol Med. 2012 Dec;154(2):274-7. doi: 10.1007/s10517-012-1929-8.
We developed a method for obtaining iron oxide nanoparticles and their conjugation with monoclonal antibodies to vascular endothelial growth factor. The resultant vector nanoparticles were low-toxic and the antibodies retained their immunochemical activity after conjugation. The study was carried out on rats with intracranial glioma C6 on day 14 after its implantation. The intravenously injected nanoparticles visualized the brain tumor in contrast to nanoparticles conjugated with nonspecific immunoglobulins that did not accumulate in the tumor.
