Verma Amit, Yadav Mange Ram, Giridhar Rajani, Prajapati Navnit, Tripathi Avinash C, Saraf Shailendra K
Pharmacy Department, Faculty of Technology & Engineering, The M S University of Baroda, Kala Bhavan, Vadodara-390001, Gujarat, India.
Comb Chem High Throughput Screen. 2013 Jun 1;16(5):345-93. doi: 10.2174/1386207311316050003.
The existence of preferred molecular scaffolds that possess inherent biological activity, called privileged structures, is now well recognized. Such privileged structures not only provide enhanced drug-like properties but also give new hits for developing leads. The synthesis of combinatorial libraries, especially with the insertion of privileged substructures into heterocyclic moieties containing nitrogen, provides for a greater probability of the discovery of novel lead compounds using chemical transformation. The review focuses on the progress in the solid-phase synthetic strategies of nitrogen containing privileged structures over the years.
具有固有生物活性的优选分子支架（即所谓的特权结构）的存在现已得到广泛认可。此类特权结构不仅具有增强的类药物性质，还为开发先导化合物提供了新的活性分子。组合文库的合成，特别是将特权子结构插入含氮杂环部分，通过化学转化更有可能发现新型先导化合物。本文综述了多年来含氮特权结构的固相合成策略的进展。
