Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark.
Acta Psychiatr Scand. 2013 Nov;128(5):370-5. doi: 10.1111/acps.12077. Epub 2013 Jan 20.
To investigate mortality and causes of death of short-lived psychotic disorders, by carrying out a comparison with bipolar disorder and schizophrenia.
Record linkage study to the official register of causes of death of all cases aged 15-64 years who were listed for the first time in the Danish Psychiatric Register between 1995 and 2008 with an ICD-10 diagnosis of 'acute and transient psychotic disorders' (ATPDs; n = 4157), bipolar disorder (n = 3200) and schizophrenia (n = 4576).
A total of 232 patients (5.6%) with ATPDs, 172 (5.4%) with bipolar disorder and 233 (5.1%) with schizophrenia had died over a mean follow-up period of 6.6 years. The standardized mortality ratio for all causes, natural causes and unnatural causes was significantly high for the three conditions. Mortality of ATPDs was greater in men, with about two-thirds of all deaths resulting from natural causes mainly cardiovascular, digestive, neoplastic and respiratory diseases. Suicide was the major cause of premature death in patients with ATPDs.
These findings suggest that ATPDs are associated with an increased mortality from both natural causes and suicide.
通过与双相情感障碍和精神分裂症进行比较，研究短暂性精神病障碍的死亡率和死亡原因。
对在 1995 年至 2008 年间首次在丹麦精神病登记处登记的所有年龄在 15 至 64 岁之间的病例进行记录链接研究，这些病例的 ICD-10 诊断为“急性和短暂性精神病障碍”（ATPD；n=4157）、双相情感障碍（n=3200）和精神分裂症（n=4576）。
在平均随访 6.6 年期间，共有 232 名（5.6%）急性和短暂性精神病障碍患者、172 名（5.4%）双相情感障碍患者和 233 名（5.1%）精神分裂症患者死亡。所有原因、自然原因和非自然原因的标准化死亡率对这三种情况都显著较高。急性和短暂性精神病障碍的死亡率在男性中较高，大约三分之二的死亡是由自然原因引起的，主要是心血管、消化、肿瘤和呼吸系统疾病。自杀是急性和短暂性精神病障碍患者过早死亡的主要原因。
这些发现表明，急性和短暂性精神病障碍与自然原因和自杀导致的死亡率增加有关。
