Department of Medicine, Duke University, Durham, NC 27707, USA.
Trends Mol Med. 2013 Feb;19(2):83-8. doi: 10.1016/j.molmed.2012.12.004. Epub 2013 Jan 14.
The androgen receptor (AR) is pivotal in the biology of sex hormone-regulated malignancies, with prostate cancer (PC) the most affected tumor. AR signals control the growth, survival, and migration of cancer cells, and they regulate the activation of macrophages, a cell type pivotal to the tumor ecosystem. Intriguingly, CaMKK2 has recently been identified as both an important AR-regulated gene in the context of PC and as a critical regulator of macrophage activation. By contrast, CaMKK2 is barely detectable in normal prostate or immune cells that mediate the response against tumorigenesis. These novel findings suggest that CaMKK2 resides at a critical molecular node that shapes the cancer ecosystem, and identifies this kinase as a novel therapeutic target for sex hormone-regulated cancers.
雄激素受体(AR)在激素调节的恶性肿瘤生物学中起着关键作用,前列腺癌(PC)是受影响最大的肿瘤。AR 信号控制癌细胞的生长、存活和迁移,并调节巨噬细胞的激活,巨噬细胞是肿瘤生态系统中至关重要的细胞类型。有趣的是,CaMKK2 最近被确定为 PC 中 AR 调节的重要基因,也是巨噬细胞激活的关键调节剂。相比之下,CaMKK2 在正常前列腺或介导抗肿瘤反应的免疫细胞中几乎检测不到。这些新发现表明,CaMKK2 位于塑造肿瘤生态系统的关键分子节点上,并将该激酶鉴定为激素调节癌症的新治疗靶点。