与纤维素相比，胶原蛋白止血剂可显著缩短止血时间：COBBANA，一项单中心、随机试验。
Collagen hemostat significantly reduces time to hemostasis compared with cellulose: COBBANA, a single-center, randomized trial.
机构信息
Department of Vascular Surgery, Klinikum Hanau GmbH, Hanau, Germany.
出版信息
Am J Surg. 2013 Jun;205(6):636-41. doi: 10.1016/j.amjsurg.2012.05.033. Epub 2013 Jan 17.
BACKGROUND
This single-center, randomized trial compares the hemostatic effectiveness of microfibrillar collagen and oxidized cellulose in arterial bypass surgery.
METHODS
In patients undergoing arterial bypass surgery, 2 hemostats, microfibrillar collagen and oxidized cellulose, were randomly used to achieve hemostasis. The primary endpoint was the time to hemostasis. The secondary endpoints were the complication rate, mortality, number of hemostats required, handling, and adhesion.
RESULTS
Collagen achieved hemostasis significantly faster than cellulose, with considerably less hemostats. In addition, its ease of use was rated substantially better.
CONCLUSION
In arterial bypass surgery, microfibrillar collagen is more effective than oxidized cellulose in achieving hemostasis.
背景
本单中心、随机试验比较了微纤维胶原蛋白和氧化纤维素在动脉旁路手术中的止血效果。
方法
在接受动脉旁路手术的患者中，随机使用 2 种止血夹，即微纤维胶原蛋白和氧化纤维素，以达到止血效果。主要终点是止血时间。次要终点是并发症发生率、死亡率、所需止血夹数量、处理和粘连。
结果
胶原蛋白止血时间明显快于纤维素，所需止血夹数量明显减少。此外，其易用性评分也明显更好。
结论
在动脉旁路手术中，微纤维胶原蛋白在止血方面比氧化纤维素更有效。
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