School of Life Sciences, University of Warwick, Coventry, UK.
Trends Neurosci. 2013 Feb;36(2):91-100. doi: 10.1016/j.tins.2012.12.008. Epub 2013 Jan 17.
Tanycytes, glial-like cells that line the third ventricle, are emerging as components of the hypothalamic networks that control body weight and energy balance. They contact the cerebrospinal fluid (CSF) and send processes that come into close contact with neurons in the arcuate and ventromedial hypothalamic nuclei. Tanycytes are glucosensitive and are able to respond to transmitters associated with arousal and the drive to feed. At least some tanycytes are stem cells and, in the median eminence, may be stimulated by diet to generate new neurons. The quest is on to understand how tanycytes detect and respond to changes in energy balance and how they communicate with the rest of the nervous system to effect their functions.
室管膜细胞是一种神经胶质样细胞，排列在第三脑室中，它们正在成为控制体重和能量平衡的下丘脑网络的组成部分。它们与脑脊液（CSF）接触，并发出与弓状核和腹内侧下丘脑核中的神经元紧密接触的突起。室管膜细胞对葡萄糖敏感，能够对与觉醒和进食驱动力相关的递质做出反应。至少一些室管膜细胞是干细胞，在正中隆起中，可能会受到饮食的刺激产生新的神经元。目前的研究旨在了解室管膜细胞如何检测和响应能量平衡的变化，以及它们如何与神经系统的其他部分进行通信以发挥其功能。
