Institute of Hygiene, Epidemiology and Public Health, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
Chemosphere. 2013 Apr;91(2):194-9. doi: 10.1016/j.chemosphere.2012.12.046. Epub 2013 Jan 17.
Brescia (North Italy) is located in a highly industrialized area with diffuse environmental pollution by polychlorinated biphenyls (PCBs) and with a high incidence of hepatocellular carcinoma (HCC). We aimed to investigate the concentration of PCBs congeners in serum, liver and adipose tissue of patients with HCC living in this area. We enrolled prospectively 101 HCC incident cases. Lipid-adjusted PCBs concentration of single congeners and total PCBs concentration, computed as the sum of 24 PCBs congeners, were measured in the serum of all subjects and in the liver and abdominal fat of 59 HCC cases undergoing surgery. A high correlation was found between PCBs serum and liver (Spearman r=0.79), serum and fat (r=0.91), and liver and fat (r=0.75) concentrations. Serum PCBs concentration in HCC patients did not vary according to demographical, clinical or epidemiological variables, apart from age, as PCBs concentration increased linearly with the subject's age. This study confirms that serum lipid-adjusted PCBs concentration is a valid measure of PCBs body storage and is highly correlated with PCBs concentration detected in other biological samples.
布雷西亚（意大利北部）位于一个高度工业化的地区，存在多氯联苯（PCBs）的弥散性环境污染，且肝细胞癌（HCC）的发病率较高。我们旨在研究生活在该地区的 HCC 患者血清、肝脏和脂肪组织中 PCBs 同系物的浓度。我们前瞻性地招募了 101 例 HCC 新发病例。对所有受试者的血清以及 59 例接受手术的 HCC 病例的肝脏和腹部脂肪中，进行了单个同系物的脂质调整 PCBs 浓度和总 PCBs 浓度（计算为 24 种 PCBs 同系物的总和）的测量。发现 PCBs 血清与肝脏（Spearman r=0.79）、血清与脂肪（r=0.91）以及肝脏与脂肪（r=0.75）之间存在高度相关性。除了年龄之外，HCC 患者的血清 PCBs 浓度与人口统计学、临床或流行病学变量无关，因为 PCBs 浓度随患者年龄呈线性增加。本研究证实，血清脂质调整后的 PCBs 浓度是 PCBs 体内储存的有效衡量标准，并且与其他生物样本中检测到的 PCBs 浓度高度相关。
