University of Eastern Finland, Department of Medicine, Institute of Public Health and Clinical Nutrition, Kuopio, Finland; Department of Internal Medicine, Lapland Central Hospital, Rovaniemi, Finland.
Int J Cardiol. 2013 Oct 3;168(3):1841-6. doi: 10.1016/j.ijcard.2012.12.072. Epub 2013 Jan 17.
Fruit and vegetable intake has been associated with lower risk for cardiovascular diseases, but data on congestive heart failure (CHF) are inconsistent. The association of serum carotenoids, biomarkers reflecting fruit and vegetable intake, with the risk of CHF has not been well documented in previous studies. We therefore examined the association between carotenoid levels and the risk of CHF.
Data were available for 1031 males aged 46 to 65 years participating in the Kuopio Ischaemic Heart Disease Risk Factor Study (Finland). Baseline data for the present study were collected between 1991 and 1993. The association between serum concentrations of carotenoids and the risk of CHF was examined by using Cox proportional hazard models.
During the median of 17.8 follow-up years, CHF occurred in 72 patients. Age and examination year adjusted risk (hazard ratio, HR) for CHF among men within the lowest quartile of serum β-carotene was 4.08 (95% CI, 1.90-8.78, p<0.001) as compared to men in the highest quartile of serum β-carotene. After further adjustment for many potential confounders, men with the lowest quartile of β-carotene had almost 3-fold increased risk of CHF (HR=2.78, 95% CI, 1.23-6.25, p=0.014). However, serum concentrations of lycopene and α-carotene were not related to the risk of CHF.
The present study suggests that low concentrations of serum β-carotene may be associated with an increased risk of CHF.
水果和蔬菜的摄入量与心血管疾病的风险降低有关，但充血性心力衰竭（CHF）的数据不一致。血清类胡萝卜素，反映水果和蔬菜摄入量的生物标志物与 CHF 风险之间的关系在以前的研究中尚未得到很好的记录。因此，我们研究了类胡萝卜素水平与 CHF 风险之间的关系。
共有 1031 名年龄在 46 至 65 岁之间的男性参与了芬兰的库奥皮奥缺血性心脏病风险因素研究（Kuopio Ischaemic Heart Disease Risk Factor Study）。本研究的基线数据收集于 1991 年至 1993 年之间。使用 Cox 比例风险模型检查血清类胡萝卜素浓度与 CHF 风险之间的关系。
在中位数为 17.8 年的随访期间，72 例患者发生 CHF。与血清β-胡萝卜素最高四分位数的男性相比，血清β-胡萝卜素最低四分位数的男性发生 CHF 的风险（危险比，HR）为 4.08（95%CI，1.90-8.78，p<0.001）。在进一步调整许多潜在混杂因素后，β-胡萝卜素最低四分位数的男性患 CHF 的风险几乎增加了 3 倍（HR=2.78，95%CI，1.23-6.25，p=0.014）。然而，血清番茄红素和α-胡萝卜素浓度与 CHF 风险无关。
本研究表明，血清β-胡萝卜素浓度低可能与 CHF 风险增加有关。
