Chen Mengli, Cai Shuyue, Jia Qinfeng, Suo Yifang, Tang Yuan, Shi Yanping, Zhu Xu, Zhang Haifeng
Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.
State Key Laboratory for Innovation and Transformation of Luobing Theory, Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
J Diabetes. 2025 Feb;17(2):e70046. doi: 10.1111/1753-0407.70046.
To examine the relationship between serum carotenoid levels and cardiovascular-kidney-metabolic (CKM) syndrome in a representative sample of US adults.
Data from the fasting subsample of the NHANES 2017-2018 were analyzed using a survey-weighted approach to ensure the findings are representative of the broader US adult population. Serum levels of α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin, and lycopene were measured using high-performance liquid chromatography. CKM syndrome stages were defined according to the 2023 American Heart Association guidelines, with advanced CKM syndrome categorized as stages 3 or 4. Associations between serum carotenoids and advanced CKM syndrome were assessed using logistic regression and weighted quantile sum (WQS) regression.
The study included 1671 adults aged 20 years and older, with a mean age of 48.7 years and a gender distribution of 50.9% female and 49.1% male. Higher serum levels of α-carotene, β-carotene, α-cryptoxanthin, lutein/zeaxanthin, and lycopene were inversely associated with advanced CKM syndrome. Specifically, compared to the lowest quartile, the highest quartile of α-carotene had an odds ratio (OR) of 0.29 (95% CI: 0.16-0.55), β-carotene 0.35 (95% CI: 0.16-0.78), α-cryptoxanthin 0.23 (95% CI: 0.11-0.49), lutein/zeaxanthin 0.26 (95% CI: 0.14-0.48), and lycopene 0.58 (95% CI: 0.35-0.98). However, β-cryptoxanthin did not show a significant association. Moreover, the combined effect of all carotenoids was significantly negatively correlated with advanced CKM syndrome (OR = 0.67, 95% CI: 0.53-0.86), with lutein/zeaxanthin contributing the most (44.56%).
Elevated serum carotenoid levels are inversely associated with the prevalence of advanced CKM syndrome in a dose-dependent manner, with this association remaining consistent across diverse demographic and health subgroups.
在美国成年人的代表性样本中研究血清类胡萝卜素水平与心血管-肾脏-代谢（CKM）综合征之间的关系。
使用调查加权方法分析了2017 - 2018年美国国家健康与营养检查调查（NHANES）空腹子样本的数据，以确保研究结果能代表更广泛的美国成年人群体。采用高效液相色谱法测量血清中α-胡萝卜素、β-胡萝卜素、β-隐黄质、叶黄素/玉米黄质和番茄红素的水平。根据2023年美国心脏协会指南定义CKM综合征阶段，将晚期CKM综合征归类为3期或4期。使用逻辑回归和加权分位数和（WQS）回归评估血清类胡萝卜素与晚期CKM综合征之间的关联。
该研究纳入了1671名20岁及以上的成年人，平均年龄为48.7岁，性别分布为女性50.9%，男性49.1%。血清中较高水平的α-胡萝卜素、β-胡萝卜素、α-隐黄质、叶黄素/玉米黄质和番茄红素与晚期CKM综合征呈负相关。具体而言，与最低四分位数相比，α-胡萝卜素最高四分位数的比值比（OR）为0.29（95%置信区间：0.16 - 0.55），β-胡萝卜素为0.35（95%置信区间：0.16 - 0.78），α-隐黄质为0.23（95%置信区间：0.11 - 0.49），叶黄素/玉米黄质为0.26（95%置信区间：0.14 - 0.48），番茄红素为0.58（95%置信区间：0.35 - 0.98）。然而，β-隐黄质未显示出显著关联。此外，所有类胡萝卜素的综合效应与晚期CKM综合征显著负相关（OR = 0.67，95%置信区间：
