Satchell P M
Gordon Craig Laboratory, Department of Surgery, University of Sydney, Australia.
Res Vet Sci. 1990 Mar;48(2):249-55.
Dogs given the neurotoxin acrylamide develop peripheral neuropathy and megaoesophagus. Sequential radiographic and manometric studies on the oesophagus demonstrated that the initial abnormalities consisted of a progressive decrease in the proportion of swallows that initiated peristalsis and a gradual increase in oesophageal calibre. Regurgitation, peristaltic failure and oesophageal dilatation all appeared within three days. The eating behaviour and gait abnormalities quickly resolved on stopping the neurotoxin, but the oesophagus remained dilated for longer. Previous studies have suggested that the abnormalities present in dogs which are developing a distal axonal neuropathy or in some dogs with idiopathic megaoesophagus may be limited to the proprioceptive elements of the oesophageal innervation. The present study suggests that the progressive inefficiency in the transmission of swallows and changes in oesophageal calibre in dogs with evolving megaoesophagus may be a consequence of damage to these proprioceptive elements.
给狗注射神经毒素丙烯酰胺会导致周围神经病变和巨食管症。对食管进行的系列放射学和测压研究表明，最初的异常表现为启动蠕动的吞咽比例逐渐下降以及食管管径逐渐增大。反流、蠕动功能衰竭和食管扩张均在三天内出现。停止使用神经毒素后，进食行为和步态异常迅速得到缓解，但食管扩张持续的时间更长。先前的研究表明，正在发展为远端轴索性神经病变的狗或一些患有特发性巨食管症的狗所出现的异常可能仅限于食管神经支配的本体感觉元件。本研究表明，患有进行性巨食管症的狗在吞咽传递方面逐渐出现的低效以及食管管径的变化可能是这些本体感觉元件受损的结果。
