Satchell P M, McLeod J G, Harper B, Goodman A H
J Neurol Neurosurg Psychiatry. 1982 Jul;45(7):609-19. doi: 10.1136/jnnp.45.7.609.
Dogs exposed to acrylamide develop a sensorimotor peripheral neuropathy and megaoesophagus. The presence of neuropathy was confirmed electrophysiologically and histologically. Hindlimb motor conduction velocity was reduced and there was a loss of large diameter myelinated fibres in the dorsal common digital nerve and the tibial nerve. The conduction velocity of vagal motor fibres innervating the thoracic oesophagus was not decreased; there was a reduction in the conduction velocity of the mixed nerve action potential of the vagus. Degenerating nerve fibres were observed in the vagus in the midthoracic region. The damage to vagal nerve fibres may be an important factor in the causation of megaoesophagus.
接触丙烯酰胺的犬会出现感觉运动性周围神经病变和巨食管症。神经病变通过电生理和组织学检查得以证实。后肢运动传导速度降低，并且在指背总神经和胫神经中出现大直径有髓纤维的丢失。支配胸段食管的迷走运动纤维的传导速度并未降低；迷走神经混合神经动作电位的传导速度有所下降。在胸段中部的迷走神经中观察到神经纤维退变。迷走神经纤维的损伤可能是导致巨食管症的一个重要因素。
