The Sackler school of Medicine, Tel Aviv University, Tel Aviv, Israel.
Pediatr Infect Dis J. 2013 Feb;32(2):120-3. doi: 10.1097/INF.0b013e3182717f0b.
The incidence and the clinical characteristics of neonatal herpes simplex virus (NHSV) infection in Israel are unknown.
We reviewed the medical records of NHSV cases who were born between January 2001 and December 2007 in 5 medical centers located in central Israel. Cases were identified using International Classification of Diseases, 9th revision codes. In addition, parents of survivors were interviewed by telephone.
In the 8-year study period, 22 cases of NHSV were identified (an incidence rate of 8.4 per 100,000 live births). Most patients (77.2%, 17 cases) manifested as skin, eye and/or mouth infection, 13.6% (3 cases) as localized central nervous system disease and 9.1% (2 cases) as disseminated disease. Most (76.4%) herpes viruses typed in our series were HSV-1. None of the mothers had documented intrapartum visible genital HSV lesions or a previous history of genital herpes. Ritual circumcision was the source of HSV-1 transmission in 7 infants (31.8% of cases).
The incidence of NHSV infection in Israel was found to be similar to the lower part of the scale reported in the United States, however higher than the incidence reported in Canada or in Europe. Similar to more recent reports, our series demonstrates the shift toward the predominance of HSV-1 in NHSV infection. In addition, none of the mothers in our series had a previous history of genital herpes. This study emphasizes the need for awareness of HSV infection in Israeli neonates.
在以色列，新生儿单纯疱疹病毒（NHSV）感染的发病率和临床特征尚不清楚。
我们回顾了 2001 年 1 月至 2007 年 12 月期间在以色列中部 5 家医疗中心出生的 NHSV 病例的医疗记录。使用国际疾病分类，第 9 版代码来识别病例。此外，通过电话采访幸存者的父母。
在 8 年的研究期间，共发现 22 例 NHSV 病例（发病率为每 100,000 例活产 8.4 例）。大多数患者（77.2%，17 例）表现为皮肤、眼睛和/或口腔感染，13.6%（3 例）为局限性中枢神经系统疾病，9.1%（2 例）为播散性疾病。我们系列中大多数（76.4%）的疱疹病毒为 HSV-1 型。母亲中没有一例有分娩时可见生殖器单纯疱疹皮损或生殖器疱疹病史的记录。在 7 例婴儿中（76.4%），HSV-1 的传播来源是宗教性割礼。
在以色列 NHSV 感染的发病率与美国报道的较低发病率相似，但高于加拿大或欧洲的发病率。与最近的报道类似，我们的系列研究表明，HSV-1 在 NHSV 感染中占主导地位的趋势。此外，我们研究中的母亲均无生殖器疱疹病史。本研究强调了对以色列新生儿单纯疱疹病毒感染的认识的必要性。
