柏科翠柏变种刺柏酚性糖苷新化合物。
A new phenolic glycoside from Chamaecyparis obtusa var. breviramea f. crippsii.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming 650201, China.
出版信息
Molecules. 2013 Jan 18;18(1):1255-61. doi: 10.3390/molecules18011255.
A new phenolic glycoside, 3-methoxyphenol 1-O-α-L-rhamnopyranosyl-(1→6)- O-β-D-glucopyranoside (1), was isolated from the 90% acetone extract of the branches and leaves of Chamaecyparis obtusa var. breviramea f. crippsii along with another 10 known phenolics 2-11. Their structures were determined mainly by means of MS, 1D- and 2D-NMR data. Cytotoxicities of compounds 3 and 5-11 were tested on BGC-823, Hela and A549 cancer cell lines, the results showed that compound 8 was bioactive and its IC(50) values were 6.9, 29.7 and 52.9 μM, respectively.
从柏科扁柏属圆柏变种翠柏的 90%丙酮提取物中分离得到一个新的酚糖苷化合物 3-甲氧基苯酚 1-O-α-L-鼠李吡喃糖基-(1→6)-O-β-D-吡喃葡萄糖苷（1），此外还分离得到另外 10 个已知的酚类化合物 2-11。它们的结构主要通过 MS、1D 和 2D-NMR 数据确定。对化合物 3 和 5-11 进行 BGC-823、Hela 和 A549 癌细胞系的细胞毒性测试，结果表明化合物 8 具有生物活性，其 IC50值分别为 6.9、29.7 和 52.9 μM。
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