Petrakos I, Kontzoglou K, Nikolopoulos T P, Papadopoulos O, Kostakis A
Department of Otorhinolaryngology, Evangelismos, General Hospital, Athens, Greece.
J BUON. 2012 Oct-Dec;17(4):700-5.
To evaluate the effectiveness of different therapeutic managements in relation to clinical disease stage, the location of the lesion and to register the rate of disease recurrence of patients with glottic and supraglottic laryngeal cancer, and to also study some specific epidemiologic characteristics.
A series of 164 patients with laryngeal glottic and supraglottic squamous cell cancer (SCC) treated surgically, with radiation therapy (RT), chemotherapy or combination of these was analysed. After treatment, all patients were followed up for an average of 58 months. All data concerning the primary lesion, therapeutic management, recurrence, staging, 5-year overall survival and epidemiological characteristics such as smoking and alcohol abuse were recorded and analysed in combination with the follow up data.
The therapeutic approach most commonly used was RT for stage I tumors and surgery for stages II, III and IV. Stage I and II patients treated with RT had high recurrence rate (60%). Patients with recurrence had 45.3% 5-year overall survival rate and average survival time 80 months, whereas patients with no recurrence had 77.4% 5-year overall survival rate and average survival time 173 months (p=0.0001). There was significant difference in survival between stage I and III (p=0.035), stage I and IV (p=0.0038) and stage II and IV (0.0156). The average overall survival time for non smokers was 195 months (median 1707rpar;, while for smokers it was 99 months (median 100; p=0.0047). The average overall survival time for alcohol abusers was 79 months (median 54), while for those who did not use alcohol it was 153 months (median 150; p=0.016).
The 5-year overall survival rate was 61.3%. RT alone in stages I and II proved inferior in decreasing re-currences compared with surgery. Smokers had significantly shorter overall survival.
评估不同治疗方法相对于临床疾病分期、病变部位的有效性，记录声门型和声门上型喉癌患者的疾病复发率，并研究一些特定的流行病学特征。
分析了164例接受手术、放射治疗（RT）、化疗或这些方法联合治疗的声门型和声门上型鳞状细胞癌（SCC）患者。治疗后，所有患者平均随访58个月。记录并分析所有关于原发病变、治疗方法、复发、分期、5年总生存率以及吸烟和酗酒等流行病学特征的数据，并结合随访数据进行分析。
最常用的治疗方法是I期肿瘤采用RT，II、III和IV期采用手术。接受RT治疗的I期和II期患者复发率较高（60%）。复发患者的5年总生存率为45.3%，平均生存时间为80个月，而未复发患者的5年总生存率为77.4%，平均生存时间为173个月（p = 0.0001）。I期和III期（p = 0.035）、I期和IV期（p = 0.0038）以及II期和IV期（0.0156）之间的生存率存在显著差异。非吸烟者的平均总生存时间为195个月（中位数170），而吸烟者为99个月（中位数100；p = 0.0047）。酗酒者的平均总生存时间为79个月（中位数54），而不饮酒者为153个月（中位数150；p = 0.016）。
5年总生存率为61.3%。与手术相比，I期和II期单独使用RT在降低复发方面效果较差。吸烟者的总生存时间明显较短。
