Mao Xionghui, Miao Susheng, He Hongjiang, Miao Suping, Pei Rong, Yang Xianguang, Xiu Chen, Song Kaibin, Zhang Jian, Sun Ji, Jia Shenshan, Guan Qiang
Department of Head and Neck Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Tumour Biol. 2014 Jan;35(1):623-9. doi: 10.1007/s13277-013-1086-3. Epub 2013 Aug 23.
Krüppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is involved in important biological processes including cell transformation, proliferation, and carcinogenesis. However, its clinical significance has remained largely unknown in laryngeal cancer. Here, specimens from 144 patients with laryngeal tumors were investigated by immunohistochemical staining for KLF5, integrin-linked kinase (ILK), and E-cadherin expressions. A clinicopathological study revealed that the KLF5 expression level in tumor cells was significantly correlated with lymph node metastasis (P < 0.05) and local recurrence (P < 0.05). In addition, KLF5, ILK, and E-cadherin (epithelial-mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that KLF5 may be an epithelial-mesenchymal transition-associated biomarker in human laryngeal carcinomas and play important roles in the progression of laryngeal carcinomas. KLF5 immunoreactivity is therefore considered a potential lymph node metastasis and recurrence factor in human laryngeal cancers. In addition, the KLF5-mediated pathway is a potential target for elimination of laryngeal cancer in the future.
Krüppel样因子5（KLF5）是一种含锌指的转录因子，参与包括细胞转化、增殖和致癌作用在内的重要生物学过程。然而，其在喉癌中的临床意义在很大程度上仍不清楚。在此，通过免疫组织化学染色对144例喉肿瘤患者的标本进行KLF5、整合素连接激酶（ILK）和E-钙黏蛋白表达情况的研究。一项临床病理研究显示，肿瘤细胞中的KLF5表达水平与淋巴结转移（P＜0.05）和局部复发（P＜0.05）显著相关。此外，KLF5、ILK和E-钙黏蛋白（上皮-间质转化（EMT）生物标志物）的表达相互关联。这些发现表明，KLF5可能是人类喉癌中与上皮-间质转化相关的生物标志物，并在喉癌进展中发挥重要作用。因此，KLF5免疫反应性被认为是人类喉癌中潜在的淋巴结转移和复发因素。此外，KLF5介导的途径是未来消除喉癌的潜在靶点。
