新型抗菌释氟单体及牙科复合材料的合成与表征
Synthesis and Characterization of New Antibacterial Fluoride-Releasing Monomer and Dental Composite.
作者信息
Wang Yapin, Samoei George K, Lallier Thomas E, Xu Xiaoming
机构信息
Department of Comprehensive Dentistry & Biomaterials, Louisiana State University Health Science, School of Dentistry, 1100 Florida Ave., New Orleans, LA 70119, USA.
出版信息
ACS Macro Lett. 2012 Dec 27;2(1):59-62. doi: 10.1021/mz300579y.
A new dimethacrylate chelating monomer containing a BisGMA-like backbone structure and a bis(carboxymethyl)-L-lysine chelating group and its ternary zirconium-fluoride complex (antibacterial fluoride-releasing monomer) have been synthesized. The monomer structures were confirmed by (1)H-NMR, (13)C-NMR, and ES-MS analysis. Several experimental fluoride-releasing dental composites containing different quantities of the new antibacterial fluoride-releasing monomer were formulated and tested for fluoride release, fluoride recharge, compressive and flexural strengths, water sorption and solubility. These composites displayed high fluoride release and recharge capabilities, as well as good physical and mechanical properties.
一种含有类似双甲基丙烯酸缩水甘油酯主链结构和双（羧甲基）-L-赖氨酸螯合基团的新型二甲基丙烯酸酯螯合单体及其三元氟化锆配合物（抗菌氟释放单体）已被合成。通过¹H-NMR、¹³C-NMR和电喷雾质谱分析确认了单体结构。配制了几种含有不同量新型抗菌氟释放单体的实验性氟释放牙科复合材料，并对其氟释放、氟再充注、抗压强度和抗弯强度、吸水性和溶解性进行了测试。这些复合材料表现出高氟释放和再充注能力，以及良好的物理和机械性能。
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